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    Nr4a1 nuclear receptor subfamily 4, group A, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 15370, updated on 12-Sep-2021

    Summary

    Official Symbol
    Nr4a1provided by MGI
    Official Full Name
    nuclear receptor subfamily 4, group A, member 1provided by MGI
    Primary source
    MGI:MGI:1352454
    See related
    Ensembl:ENSMUSG00000023034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gf; Hm; N1; NP; TI; TR; GFR; Hbr; Hmr; N10; Nur; TR3; Gfrp; Hbr-; Hbr1; NGFI; NP10; TIS1; GFRP1; Hbr-1; NGFIB; nur77; NGFI-B; NUR77-1; NUR77-2
    Expression
    Biased expression in adrenal adult (RPKM 65.6), thymus adult (RPKM 24.0) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nr4a1 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101151788..101172676)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101253902..101274795)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (101097277..101105226)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330009N23 gene Neighboring gene expressed sequence AU021063 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene predicted gene, 53913 Neighboring gene autophagy related 101 Neighboring gene small integral membrane protein 41 Neighboring gene predicted gene, 41403

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glucocorticoid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to corticotropin-releasing hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to corticotropin-releasing hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter secretion involved in regulation of skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amphetamine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to inorganic substance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor subfamily 4 group A member 1
    Names
    hormone receptor
    nuclear hormone receptor NUR/77
    nuclear protein N10
    orphan nuclear receptor HMR

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010444.2NP_034574.1  nuclear receptor subfamily 4 group A member 1

      See identical proteins and their annotated locations for NP_034574.1

      Status: VALIDATED

      Source sequence(s)
      AA930162, AK004709, BY292808
      Consensus CDS
      CCDS27848.1
      UniProtKB/Swiss-Prot
      P12813
      UniProtKB/TrEMBL
      Q545Q1
      Related
      ENSMUSP00000023779.7, ENSMUST00000023779.8
      Conserved Domains (2) summary
      cd07348
      Location:364601
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:268342
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101151788..101172676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248339.2XP_030104199.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      Conserved Domains (2) summary
      cd07348
      Location:364601
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:268342
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    2. XM_006520456.2XP_006520519.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      See identical proteins and their annotated locations for XP_006520519.1

      UniProtKB/Swiss-Prot
      P12813
      UniProtKB/TrEMBL
      Q545Q1
      Related
      ENSMUSP00000155225.2, ENSMUST00000228985.2
      Conserved Domains (2) summary
      cd07348
      Location:364601
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:268342
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    3. XM_017316436.3XP_017171925.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      UniProtKB/Swiss-Prot
      P12813
      UniProtKB/TrEMBL
      Q545Q1
      Conserved Domains (2) summary
      cd07348
      Location:364601
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:268342
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    4. XM_036159163.1XP_036015056.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      Conserved Domains (2) summary
      cd07348
      Location:364601
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:268342
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    5. XM_006520459.5XP_006520522.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      See identical proteins and their annotated locations for XP_006520522.1

      UniProtKB/Swiss-Prot
      P12813
      UniProtKB/TrEMBL
      Q545Q1
      Conserved Domains (2) summary
      cd07348
      Location:364601
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:268342
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    6. XM_006520455.2XP_006520518.2  nuclear receptor subfamily 4 group A member 1 isoform X1

      Conserved Domains (2) summary
      cd07348
      Location:364601
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:268342
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    RNA

    1. XR_004938795.1 RNA Sequence

    2. XR_004938796.1 RNA Sequence

    3. XR_004938794.1 RNA Sequence

    4. XR_004938797.1 RNA Sequence

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