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    Hck hemopoietic cell kinase [ Mus musculus (house mouse) ]

    Gene ID: 15162, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hckprovided by MGI
    Official Full Name
    hemopoietic cell kinaseprovided by MGI
    Primary source
    MGI:MGI:96052
    See related
    Ensembl:ENSMUSG00000003283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmk; AI849071
    Summary
    The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]
    Expression
    Biased expression in spleen adult (RPKM 38.8), lung adult (RPKM 21.0) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Hck in Genome Data Viewer
    Location:
    2 H1; 2 75.41 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152950388..152993361)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153108468..153151441)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (152934204..152977177)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related 7 Neighboring gene predicted gene, 32286 Neighboring gene cerebral cavernous malformation 2-like Neighboring gene transmembrane 9 superfamily member 4 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene TSPY-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC18625

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within defense response to Gram-positive bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase HCK
    Names
    B cell/myeloid kinase
    hematopoietic cell kinase
    p56-HCK/p59-HCK
    NP_001165588.1
    NP_034537.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172117.1NP_001165588.1  tyrosine-protein kinase HCK isoform p56Hck

      See identical proteins and their annotated locations for NP_001165588.1

      Status: REVIEWED

      Description
      Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons, as demonstrated in PMID:1875927. The longer isoform (p59Hck) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (p56Hck) is derived from a downstream AUG start codon. The shorter isoform (p56Hck) is represented in this RefSeq.
      Source sequence(s)
      AI849071, AK150290, BY157889
      Consensus CDS
      CCDS50756.1
      UniProtKB/Swiss-Prot
      P08103
      Related
      ENSMUSP00000105423.2, ENSMUST00000109799.8
      Conserved Domains (4) summary
      cd10363
      Location:117220
      SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
      pfam07714
      Location:239488
      Pkinase_Tyr; Protein tyrosine kinase
      cl17036
      Location:59114
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:231501
      PKc_like; Protein Kinases, catalytic domain
    2. NM_010407.4NP_034537.2  tyrosine-protein kinase HCK isoform p59Hck

      See identical proteins and their annotated locations for NP_034537.2

      Status: REVIEWED

      Description
      Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons, as demonstrated in PMID:1875927. The longer isoform (p59Hck) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (p56Hck) is derived from a downstream AUG start codon. The longer isoform (p59Hck) is represented in this RefSeq.
      Source sequence(s)
      AI849071, AK150290, BY157889
      Consensus CDS
      CCDS38284.1
      UniProtKB/Swiss-Prot
      P08103
      UniProtKB/TrEMBL
      A0A087WQ04
      Related
      ENSMUSP00000003370.8, ENSMUST00000003370.14
      Conserved Domains (4) summary
      cd10363
      Location:138241
      SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
      pfam07714
      Location:260509
      Pkinase_Tyr; Protein tyrosine kinase
      cl17036
      Location:80135
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:252522
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152950388..152993361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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