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    CPE carboxypeptidase E [ Homo sapiens (human) ]

    Gene ID: 1363, updated on 25-Nov-2021

    Summary

    Official Symbol
    CPEprovided by HGNC
    Official Full Name
    carboxypeptidase Eprovided by HGNC
    Primary source
    HGNC:HGNC:2303
    See related
    Ensembl:ENSG00000109472 MIM:114855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPH; BDVS; IDDHH
    Summary
    This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in brain (RPKM 491.8), prostate (RPKM 192.3) and 11 other tissues See more
    Orthologs
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    Genomic context

    See CPE in Genome Data Viewer
    Location:
    4q32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (165379008..165498547)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (166300160..166419699)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene methylsterol monooxygenase 1 Neighboring gene uncharacterized LOC105377519 Neighboring gene microRNA 578 Neighboring gene HADHA pseudogene 1 Neighboring gene uncharacterized LOC105377520 Neighboring gene secretoglobin family 1D member 5, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxypeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables neurexin family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cardiac left ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular protein modification process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in insulin processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in peptide hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein localization to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in secretory granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    carboxypeptidase E
    Names
    carbocypeptidase E
    carboxypeptidase H
    cobalt-stimulated chromaffin granule carboxypeptidase
    enkephalin convertase
    epididymis secretory sperm binding protein
    insulin granule-associated carboxypeptidase
    prohormone-processing carboxypeptidase
    NP_001864.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001873.4NP_001864.1  carboxypeptidase E preproprotein

      See identical proteins and their annotated locations for NP_001864.1

      Status: REVIEWED

      Source sequence(s)
      AA683379, AA883804, AC012504, X51405
      Consensus CDS
      CCDS3810.1
      UniProtKB/Swiss-Prot
      P16870
      Related
      ENSP00000386104.4, ENST00000402744.9
      Conserved Domains (2) summary
      cd03865
      Location:49371
      M14_CPE; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase E subgroup
      cd11308
      Location:375449
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      165379008..165498547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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