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    Ctss cathepsin S [ Mus musculus (house mouse) ]

    Gene ID: 13040, updated on 12-Sep-2021

    Summary

    Official Symbol
    Ctssprovided by MGI
    Official Full Name
    cathepsin Sprovided by MGI
    Primary source
    MGI:MGI:107341
    See related
    Ensembl:ENSMUSG00000038642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cats
    Summary
    This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in spleen adult (RPKM 32.7), large intestine adult (RPKM 28.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Ctss in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95434097..95463716)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95526786..95556405)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (95330708..95360325)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cathepsin K Neighboring gene predicted gene, 40096 Neighboring gene high mobility group box 1, pseudogene 5 Neighboring gene HORMA domain containing 1 Neighboring gene predicted gene, 40097 Neighboring gene golgi phosphoprotein 3-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen processing and presentation of peptide antigen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in basement membrane disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in basement membrane disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis involved in cellular protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis involved in cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cathepsin S
    Names
    Cat S
    NP_001254624.2
    NP_067256.4
    XP_006501038.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267695.2NP_001254624.2  cathepsin S isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC092203, AK028366, AK150274, BB072817
      Consensus CDS
      CCDS71291.1
      UniProtKB/TrEMBL
      F6WR04, Q3UD32, Q8BSZ5
      Related
      ENSMUSP00000015667.4, ENSMUST00000015667.9
      Conserved Domains (2) summary
      smart00848
      Location:3796
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:124339
      Peptidase_C1; Papain family cysteine protease
    2. NM_021281.3NP_067256.4  cathepsin S isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_067256.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AK028366, BB072817
      Consensus CDS
      CCDS50992.1
      UniProtKB/Swiss-Prot
      O70370
      UniProtKB/TrEMBL
      Q8BSZ5
      Related
      ENSMUSP00000112006.3, ENSMUST00000116304.3
      Conserved Domains (2) summary
      smart00848
      Location:3695
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:123338
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95434097..95463716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500975.4XP_006501038.2  cathepsin S isoform X1

      Conserved Domains (1) summary
      pfam00112
      Location:42257
      Peptidase_C1; Papain family cysteine protease
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