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    Dmbt1 deleted in malignant brain tumors 1 [ Mus musculus (house mouse) ]

    Gene ID: 12945, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dmbt1provided by MGI
    Official Full Name
    deleted in malignant brain tumors 1provided by MGI
    Primary source
    MGI:MGI:106210
    See related
    Ensembl:ENSMUSG00000047517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cr; he; CRP; MUC; ebn; p80; CRP-; Crpd; gp30; CRP-[; DBMT1; gp300; CRP-[a]; CRP-[b]
    Expression
    Biased expression in colon adult (RPKM 494.9), large intestine adult (RPKM 367.0) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dmbt1 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (130633787..130723357)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131032057..131121628)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (138175590..138265142)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 Neighboring gene microRNA 7061 Neighboring gene HtrA serine peptidase 1 Neighboring gene RIKEN cDNA 4933402N03 gene Neighboring gene RIKEN cDNA 1700029B22 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables heparan sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipoteichoic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zymogen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of bacterial lipoprotein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in induction of bacterial agglutination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner cell mass cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in zymogen granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    deleted in malignant brain tumors 1 protein
    Names
    apactin
    crp-ductin
    deleted in malignant brain tumors 1 pseudogene
    ebnerin
    glycoprotein 300
    hensin
    mucin-like glycoprotein
    muclin
    vomeroglandin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347632.2NP_001334561.1  deleted in malignant brain tumors 1 protein isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB005909, AC087063, AC110885, LXEJ02004976
      Consensus CDS
      CCDS85436.1
      UniProtKB/Swiss-Prot
      Q60997
      Related
      ENSMUSP00000146685.3, ENSMUST00000208311.4
    2. NM_007769.3NP_031795.2  deleted in malignant brain tumors 1 protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_031795.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB005909, AC087063, AC110885, LXEJ02004976
      Consensus CDS
      CCDS21909.1
      UniProtKB/Swiss-Prot
      Q60997
      Related
      ENSMUSP00000081556.5, ENSMUST00000084509.7
      Conserved Domains (5) summary
      smart00202
      Location:324424
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:16131860
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:14941602
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00100
      Location:17311858
      Zona_pellucida; Zona pellucida-like domain
      pfam00530
      Location:13761471
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      130633787..130723357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507307.5XP_006507370.2  deleted in malignant brain tumors 1 protein isoform X9

      Conserved Domains (2) summary
      smart00202
      Location:439539
      SR; Scavenger receptor Cys-rich
      cd00041
      Location:9991107
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    2. XM_006507302.5XP_006507365.2  deleted in malignant brain tumors 1 protein isoform X5

      Conserved Domains (3) summary
      smart00202
      Location:439539
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:17281975
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:16091717
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    3. XM_006507298.5XP_006507361.2  deleted in malignant brain tumors 1 protein isoform X1

      Conserved Domains (3) summary
      smart00202
      Location:439539
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:17281975
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:16091717
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    4. XM_006507299.5XP_006507362.2  deleted in malignant brain tumors 1 protein isoform X2

      Conserved Domains (3) summary
      smart00202
      Location:439539
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:17181965
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:15991707
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    5. XM_006507304.5XP_006507367.2  deleted in malignant brain tumors 1 protein isoform X6

      Conserved Domains (3) summary
      smart00202
      Location:439539
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:16021849
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:14831591
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    6. XM_006507306.5XP_006507369.2  deleted in malignant brain tumors 1 protein isoform X8

      Related
      ENSMUSP00000148657.2, ENSMUST00000213064.3
      Conserved Domains (3) summary
      smart00202
      Location:439539
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:15891836
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:14701578
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    7. XM_006507305.5XP_006507368.2  deleted in malignant brain tumors 1 protein isoform X7

      Conserved Domains (3) summary
      smart00202
      Location:718818
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:15901837
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:14711579
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    8. XM_006507301.5XP_006507364.2  deleted in malignant brain tumors 1 protein isoform X4

      Conserved Domains (3) summary
      smart00202
      Location:428528
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:17171964
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:15981706
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    9. XM_006507300.5XP_006507363.2  deleted in malignant brain tumors 1 protein isoform X3

      Conserved Domains (3) summary
      smart00202
      Location:428528
      SR; Scavenger receptor Cys-rich
      smart00241
      Location:17171964
      ZP; Zona pellucida (ZP) domain
      cd00041
      Location:15981706
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_019334.1: Suppressed sequence

      Description
      NG_019334.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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