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    Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) [ Mus musculus (house mouse) ]

    Gene ID: 12577, updated on 24-Aug-2021

    Summary

    Official Symbol
    Cdkn1cprovided by MGI
    Official Full Name
    cyclin-dependent kinase inhibitor 1C (P57)provided by MGI
    Primary source
    MGI:MGI:104564
    See related
    Ensembl:ENSMUSG00000037664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ki; CDK; CDKI; Kip2; p57K; p57Kip2; AL024410; p57(kip2)
    Expression
    Biased expression in limb E14.5 (RPKM 280.3), adrenal adult (RPKM 244.3) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cdkn1c in Genome Data Viewer
    Location:
    7 F5; 7 88.22 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143012076..143014802, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143458339..143461059, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (150644244..150646955, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily Q, member 1 Neighboring gene KCNQ1 overlapping transcript 1 Neighboring gene RIKEN cDNA 4933417O13 gene Neighboring gene predicted gene, 33663 Neighboring gene solute carrier family 22 (organic cation transporter), member 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adrenal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within digestive system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic placenta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of exit from mitosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of lens fiber cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within uterus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase inhibitor 1C
    Names
    cyclin-dependent kinase inhibitor p57

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161624.1NP_001155096.1  cyclin-dependent kinase inhibitor 1C isoform 1

      See identical proteins and their annotated locations for NP_001155096.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA986859, CJ175313, U20553, U22399
      Consensus CDS
      CCDS52463.1
      UniProtKB/Swiss-Prot
      P49919
      Related
      ENSMUSP00000128828.2, ENSMUST00000167912.9
      Conserved Domains (2) summary
      PTZ00341
      Location:197281
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:3481
      CDI; Cyclin-dependent kinase inhibitor
    2. NM_001354981.1NP_001341910.1  cyclin-dependent kinase inhibitor 1C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC023248
      Consensus CDS
      CCDS22040.1
      Conserved Domains (2) summary
      PTZ00341
      Location:184268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:2168
      CDI; Cyclin-dependent kinase inhibitor
    3. NM_009876.4NP_034006.3  cyclin-dependent kinase inhibitor 1C isoform 2

      See identical proteins and their annotated locations for NP_034006.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AA986859, CJ175313, U22399
      Consensus CDS
      CCDS22040.1
      UniProtKB/Swiss-Prot
      P49919
      UniProtKB/TrEMBL
      Q791X1
      Related
      ENSMUSP00000037302.7, ENSMUST00000037287.8
      Conserved Domains (2) summary
      PTZ00341
      Location:184268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:2168
      CDI; Cyclin-dependent kinase inhibitor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143012076..143014802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242048.2XP_030097908.1  cyclin-dependent kinase inhibitor 1C isoform X4

      Conserved Domains (2) summary
      PTZ00341
      Location:184268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:2168
      CDI; Cyclin-dependent kinase inhibitor
    2. XM_030242046.2XP_030097906.1  cyclin-dependent kinase inhibitor 1C isoform X3

      Conserved Domains (2) summary
      PTZ00341
      Location:184268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:2168
      CDI; Cyclin-dependent kinase inhibitor
    3. XM_006508470.5XP_006508533.1  cyclin-dependent kinase inhibitor 1C isoform X3

      See identical proteins and their annotated locations for XP_006508533.1

      Conserved Domains (2) summary
      PTZ00341
      Location:184268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:2168
      CDI; Cyclin-dependent kinase inhibitor
    4. XM_030242047.2XP_030097907.1  cyclin-dependent kinase inhibitor 1C isoform X4

      Conserved Domains (2) summary
      PTZ00341
      Location:184268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:2168
      CDI; Cyclin-dependent kinase inhibitor
    5. XM_030242045.2XP_030097905.1  cyclin-dependent kinase inhibitor 1C isoform X3

      Conserved Domains (2) summary
      PTZ00341
      Location:184268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:2168
      CDI; Cyclin-dependent kinase inhibitor
    6. XM_006508469.5XP_006508532.1  cyclin-dependent kinase inhibitor 1C isoform X3

      See identical proteins and their annotated locations for XP_006508532.1

      Conserved Domains (2) summary
      PTZ00341
      Location:184268
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:2168
      CDI; Cyclin-dependent kinase inhibitor
    7. XM_030242044.2XP_030097904.1  cyclin-dependent kinase inhibitor 1C isoform X2

      Conserved Domains (2) summary
      PTZ00341
      Location:197281
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:3481
      CDI; Cyclin-dependent kinase inhibitor
    8. XM_006508468.5XP_006508531.1  cyclin-dependent kinase inhibitor 1C isoform X1

      See identical proteins and their annotated locations for XP_006508531.1

      Conserved Domains (2) summary
      PTZ00341
      Location:197281
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:3481
      CDI; Cyclin-dependent kinase inhibitor
    9. XM_006508467.5XP_006508530.1  cyclin-dependent kinase inhibitor 1C isoform X1

      See identical proteins and their annotated locations for XP_006508530.1

      Conserved Domains (2) summary
      PTZ00341
      Location:197281
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      pfam02234
      Location:3481
      CDI; Cyclin-dependent kinase inhibitor
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