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    Axin1 axin 1 [ Mus musculus (house mouse) ]

    Gene ID: 12005, updated on 1-Oct-2021

    Summary

    Official Symbol
    Axin1provided by MGI
    Official Full Name
    axin 1provided by MGI
    Primary source
    MGI:MGI:1096327
    See related
    Ensembl:ENSMUSG00000024182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fu; Kb; Ki; Axin; fused; kinky; knobbly; AI316800
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.6), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Axin1 in Genome Data Viewer
    Location:
    17 A3.3; 17 13.07 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26350208..26414785)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26131217..26195811)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (26275631..26332756)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene post-glycosylphosphatidylinositol attachment to proteins 6 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene protein disulfide isomerase associated 2 Neighboring gene Rho GDP dissociation inhibitor (GDI) gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC132911

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables I-SMAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables I-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein C-terminus binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor complex adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within Wnt signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within axial mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axial mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytoplasmic microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemoglobin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription elongation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within nervous system process IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-anal tail morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Wnt signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of beta-catenin destruction complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    axin-1
    Names
    axis inhibition protein 1
    protein Fused

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159598.2NP_001153070.2  axin-1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC126438, AC140047
      Consensus CDS
      CCDS50042.1
      Related
      ENSMUSP00000132000.2, ENSMUST00000163421.8
      Conserved Domains (3) summary
      cd08707
      Location:89209
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:745827
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1180
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    2. NM_001394381.1NP_001381310.1  axin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126438, AC140047
      Conserved Domains (4) summary
      cd08707
      Location:89209
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1180
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:783860
      DIX; DIX domain
      pfam08833
      Location:464495
      Axin_b-cat_bind; Axin beta-catenin binding domain
    3. NM_001394382.1NP_001381311.1  axin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126438, AC140047
      Conserved Domains (3) summary
      cd08707
      Location:89209
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:745827
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1180
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    4. NM_001394389.1NP_001381318.1  axin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC126438, AC140047
      Conserved Domains (3) summary
      cd08707
      Location:89209
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      smart00021
      Location:745827
      DAX; Domain present in Dishevelled and axin
      cd11582
      Location:1180
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    5. NM_009733.3NP_033863.3  axin-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1, resulting in a longer protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC126438, AC140047
      Consensus CDS
      CCDS28547.2
      Related
      ENSMUSP00000073974.4, ENSMUST00000074370.10
      Conserved Domains (4) summary
      cd08707
      Location:89209
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1180
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:783860
      DIX; DIX domain
      pfam08833
      Location:464495
      Axin_b-cat_bind; Axin beta-catenin binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26350208..26414785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523515.5XP_006523578.1  axin-1 isoform X1

      UniProtKB/TrEMBL
      E9QMJ8
      Conserved Domains (4) summary
      cd08707
      Location:94214
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1685
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:788863
      DIX; DIX domain
      pfam08833
      Location:468521
      Axin_b-cat_bind; Axin beta-catenin binding domain
    2. XM_030249451.2XP_030105311.1  axin-1 isoform X2

      Conserved Domains (4) summary
      cd08707
      Location:94214
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1685
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:752827
      DIX; DIX domain
      pfam08833
      Location:468521
      Axin_b-cat_bind; Axin beta-catenin binding domain
    3. XM_030249452.2XP_030105312.1  axin-1 isoform X2

      Conserved Domains (4) summary
      cd08707
      Location:94214
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1685
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:752827
      DIX; DIX domain
      pfam08833
      Location:468521
      Axin_b-cat_bind; Axin beta-catenin binding domain
    4. XM_006523516.3XP_006523579.1  axin-1 isoform X3

      Conserved Domains (2) summary
      pfam00778
      Location:428503
      DIX; DIX domain
      pfam08833
      Location:108161
      Axin_b-cat_bind; Axin beta-catenin binding domain
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