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    Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 [ Mus musculus (house mouse) ]

    Gene ID: 11975, updated on 25-Nov-2021

    Summary

    Official Symbol
    Atp6v0a1provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit A1provided by MGI
    Primary source
    MGI:MGI:103286
    See related
    Ensembl:ENSMUSG00000019302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vpp1; Vpp-1; ATP6a1; Atp6n1; Atp6n1a; Atpv0a1; AA959968
    Expression
    Ubiquitous expression in cortex adult (RPKM 75.9), frontal lobe adult (RPKM 74.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp6v0a1 in Genome Data Viewer
    Location:
    11 D; 11 64.04 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100899262..100954545)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101009422..101063719)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100870769..100925028)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 3 Neighboring gene predicted gene, 46295 Neighboring gene caveolae associated 1 Neighboring gene microRNA 6928 Neighboring gene alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 
    • Endonuclease-mediated (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase 116 kDa subunit a1
    Names
    ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1 (110/160 kDa)
    ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic accessory protein 1A (110/160 kDa)
    ATPase, H+ transporting, lysosomal V0 subunit a
    V-ATPase 116 kDa subunit a1
    V-ATPase a1
    V-type proton ATPase 116 kDa subunit a
    clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit
    vacuolar adenosine triphosphatase subunit Ac116
    vacuolar proton pump subunit 1
    vacuolar proton translocating ATPase 116 kDa subunit a
    NP_001229978.1
    NP_001229979.1
    NP_001229980.1
    NP_001349565.1
    NP_001349566.1
    NP_001349567.1
    NP_001349568.1
    NP_001349569.1
    NP_001349570.1
    NP_058616.1
    XP_006532112.1
    XP_006532113.1
    XP_006532114.1
    XP_006532117.1
    XP_006532118.1
    XP_030101351.1
    XP_030101352.1
    XP_036012144.1
    XP_036012145.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243049.2NP_001229978.1  V-type proton ATPase 116 kDa subunit a1 isoform 2

      See identical proteins and their annotated locations for NP_001229978.1

      Status: VALIDATED

      Source sequence(s)
      AI838682, AK158786, AK159114, AL591425, CJ143241
      UniProtKB/TrEMBL
      Q3TXT5, Q3TY98
      Conserved Domains (1) summary
      pfam01496
      Location:1769
      V_ATPase_I; V-type ATPase 116kDa subunit family
    2. NM_001243050.2NP_001229979.1  V-type proton ATPase 116 kDa subunit a1 isoform 3

      See identical proteins and their annotated locations for NP_001229979.1

      Status: VALIDATED

      Source sequence(s)
      AF218251, AI838682, AK159114, AL591425, CJ143241
      Consensus CDS
      CCDS56809.1
      UniProtKB/Swiss-Prot
      Q9Z1G4
      UniProtKB/TrEMBL
      Q3TXT5
      Related
      ENSMUSP00000090333.4, ENSMUST00000092663.4
      Conserved Domains (2) summary
      COG1269
      Location:27823
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28822
      V_ATPase_I; V-type ATPase 116kDa subunit family
    3. NM_001243051.2NP_001229980.1  V-type proton ATPase 116 kDa subunit a1 isoform 4

      See identical proteins and their annotated locations for NP_001229980.1

      Status: VALIDATED

      Source sequence(s)
      AI838682, AK158786, AK159114, AL591425, AW318708, CJ143241
      Consensus CDS
      CCDS56808.1
      UniProtKB/Swiss-Prot
      Q9Z1G4
      UniProtKB/TrEMBL
      Q3TXT5, Q3TY98
      Related
      ENSMUSP00000099399.4, ENSMUST00000103110.10
      Conserved Domains (2) summary
      COG1269
      Location:27830
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28829
      V_ATPase_I; V-type ATPase 116kDa subunit family
    4. NM_001362636.1NP_001349565.1  V-type proton ATPase 116 kDa subunit a1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AI838682, AL591425
      Conserved Domains (1) summary
      pfam01496
      Location:27853
      V_ATPase_I; V-type ATPase 116kDa subunit family
    5. NM_001362637.1NP_001349566.1  V-type proton ATPase 116 kDa subunit a1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AI838682, AL591425
      Conserved Domains (1) summary
      pfam01496
      Location:27835
      V_ATPase_I; V-type ATPase 116kDa subunit family
    6. NM_001362638.1NP_001349567.1  V-type proton ATPase 116 kDa subunit a1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI838682, AL591425
      Consensus CDS
      CCDS25443.1
      Conserved Domains (1) summary
      pfam01496
      Location:27828
      V_ATPase_I; V-type ATPase 116kDa subunit family
    7. NM_001362639.1NP_001349568.1  V-type proton ATPase 116 kDa subunit a1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AI838682, AL591425
      Conserved Domains (1) summary
      pfam01496
      Location:1768
      V_ATPase_I; V-type ATPase 116kDa subunit family
    8. NM_001362640.1NP_001349569.1  V-type proton ATPase 116 kDa subunit a1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL591425
      Conserved Domains (1) summary
      pfam01496
      Location:27669
      V_ATPase_I; V-type ATPase 116kDa subunit family
    9. NM_001362641.1NP_001349570.1  V-type proton ATPase 116 kDa subunit a1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL591425
      Conserved Domains (1) summary
      cl27549
      Location:27221
      V_ATPase_I; V-type ATPase 116kDa subunit family
    10. NM_016920.4NP_058616.1  V-type proton ATPase 116 kDa subunit a1 isoform 1

      See identical proteins and their annotated locations for NP_058616.1

      Status: VALIDATED

      Source sequence(s)
      AI838682, AK029316, AK158786, AK159114, AL591425
      Consensus CDS
      CCDS25443.1
      UniProtKB/Swiss-Prot
      Q9Z1G4
      UniProtKB/TrEMBL
      Q3TXT5, Q3TY98
      Related
      ENSMUSP00000044838.7, ENSMUST00000044721.13
      Conserved Domains (1) summary
      pfam01496
      Location:27828
      V_ATPase_I; V-type ATPase 116kDa subunit family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100899262..100954545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532049.4XP_006532112.1  V-type proton ATPase 116 kDa subunit a1 isoform X1

      Conserved Domains (1) summary
      pfam01496
      Location:27860
      V_ATPase_I; V-type ATPase 116kDa subunit family
    2. XM_006532051.4XP_006532114.1  V-type proton ATPase 116 kDa subunit a1 isoform X3

      Conserved Domains (1) summary
      pfam01496
      Location:27854
      V_ATPase_I; V-type ATPase 116kDa subunit family
    3. XM_006532055.4XP_006532118.1  V-type proton ATPase 116 kDa subunit a1 isoform X7

      Conserved Domains (1) summary
      pfam01496
      Location:27793
      V_ATPase_I; V-type ATPase 116kDa subunit family
    4. XM_006532050.4XP_006532113.1  V-type proton ATPase 116 kDa subunit a1 isoform X2

      Conserved Domains (1) summary
      pfam01496
      Location:27854
      V_ATPase_I; V-type ATPase 116kDa subunit family
    5. XM_036156251.1XP_036012144.1  V-type proton ATPase 116 kDa subunit a1 isoform X4

      Conserved Domains (1) summary
      pfam01496
      Location:27848
      V_ATPase_I; V-type ATPase 116kDa subunit family
    6. XM_006532054.3XP_006532117.1  V-type proton ATPase 116 kDa subunit a1 isoform X5

      Conserved Domains (1) summary
      pfam01496
      Location:27829
      V_ATPase_I; V-type ATPase 116kDa subunit family
    7. XM_030245491.2XP_030101351.1  V-type proton ATPase 116 kDa subunit a1 isoform X6

      Conserved Domains (1) summary
      pfam01496
      Location:27823
      V_ATPase_I; V-type ATPase 116kDa subunit family
    8. XM_036156252.1XP_036012145.1  V-type proton ATPase 116 kDa subunit a1 isoform X8

      Conserved Domains (1) summary
      pfam01496
      Location:27787
      V_ATPase_I; V-type ATPase 116kDa subunit family
    9. XM_030245492.2XP_030101352.1  V-type proton ATPase 116 kDa subunit a1 isoform X9

      Conserved Domains (1) summary
      pfam01496
      Location:27786
      V_ATPase_I; V-type ATPase 116kDa subunit family

    RNA

    1. XR_388335.3 RNA Sequence

    2. XR_388336.3 RNA Sequence

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