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    Fbp2 fructose-bisphosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114508, updated on 30-Sep-2021

    Summary

    Official Symbol
    Fbp2provided by RGD
    Official Full Name
    fructose-bisphosphatase 2provided by RGD
    Primary source
    RGD:620930
    See related
    EnsemblRapid:ENSRNOG00000017637
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FBPase
    Summary
    last key-enzyme before the synthesis of glucose-6-phosphate of the gluconeogenic pathway [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 425.9), Testes (RPKM 83.5) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Fbp2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (2236088..2253702)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (372554..389918, complement)

    Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551048 Neighboring gene fructose-bisphosphatase 1 Neighboring gene zinc finger protein 431-like Neighboring gene zinc finger protein 431-like Neighboring gene V-type proton ATPase subunit G 1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sucrose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fructose-1,6-bisphosphatase isozyme 2
    Names
    D-fructose-1,6-bisphosphate 1-phosphohydrolase 2
    FBPase 2
    fructose-1,6-bisphosphatase 2
    muscle FBPase
    NP_446168.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053716.2NP_446168.1  fructose-1,6-bisphosphatase isozyme 2

      See identical proteins and their annotated locations for NP_446168.1

      Status: PROVISIONAL

      Source sequence(s)
      JACYVU010000284
      UniProtKB/Swiss-Prot
      Q9Z1N1
      Related
      ENSRNOP00000023865.2, ENSRNOT00000023865.4
      Conserved Domains (1) summary
      cd00354
      Location:18330
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

      Range
      2236088..2253702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005495224.1 RNA Sequence

    2. XR_005495225.1 RNA Sequence

    3. XR_005495226.1 RNA Sequence

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