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    Gpnmb glycoprotein nmb [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113955, updated on 30-Sep-2021

    Summary

    Official Symbol
    Gpnmbprovided by RGD
    Official Full Name
    glycoprotein nmbprovided by RGD
    Primary source
    RGD:71008
    See related
    EnsemblRapid:ENSRNOG00000008816
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may play a role in bone matrix production and mineralization; overexpressed in the osteopetrosis mutant op rat [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 680.2), Lung (RPKM 437.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Gpnmb in Genome Data Viewer
    Location:
    4q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (78010247..78031491)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78694447..78715685)

    Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 1 Neighboring gene uncharacterized LOC102546557 Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene insulin-like growth factor 2 mRNA binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables syndecan binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bone mineralization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transmembrane glycoprotein NMB
    Names
    glycoprotein (transmembrane) nmb
    osteoactivin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133298.1NP_579832.1  transmembrane glycoprotein NMB precursor

      See identical proteins and their annotated locations for NP_579832.1

      Status: PROVISIONAL

      Source sequence(s)
      AF184983
      UniProtKB/TrEMBL
      Q9QZF6
      Related
      ENSRNOP00000076498.1, ENSRNOT00000104789.1
      Conserved Domains (1) summary
      cd00146
      Location:263316
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

      Range
      78010247..78031491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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