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    Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [ Mus musculus (house mouse) ]

    Gene ID: 100037258, updated on 16-Oct-2021

    Summary

    Official Symbol
    Dnajc3provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C3provided by MGI
    Primary source
    MGI:MGI:107373
    See related
    Ensembl:ENSMUSG00000022136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p58; mp58; Prkri; p58IPK; Dnajc3a; Dnajc3b; AA408985; AU067833
    Annotation information
    Note: On Build36, NCBI annotated NC_000080.4:117820545..117862457 as Dnajc3 with MGI:107373. Mouse Genome Informatics (MGI) defined that location as Dnajc3b, MGI:3696572. On April 10, 2006, NCBI renamed that location to conform to the definition by MGI. With Build37, the duplicate annotation was no longer required, because the component CT025524.8 was removed from the assembly. [13 Feb 2013]
    Expression
    Ubiquitous expression in placenta adult (RPKM 26.5), genital fat pad adult (RPKM 18.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dnajc3 in Genome Data Viewer
    Location:
    14; 14 E4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (119175344..119219114)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118937932..118981702)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (119337154..119380924)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene claudin 10 Neighboring gene predicted gene, 32382 Neighboring gene DAZ interacting protein 1 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene predicted gene, 16835 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene tera pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6474

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chaperone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables misfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 3
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 3
    DnaJ (Hsp40) homolog, subfamily C, member 3A
    DnaJ (Hsp40) homolog, subfamily C, member 3B
    interferon-induced, double-stranded RNA-activated protein kinase inhibitor
    protein kinase inhibitor of 58 kDa
    protein kinase inhibitor p58
    protein kinase, interferon inducible double stranded RNA dependent inhibitor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008929.3NP_032955.2  dnaJ homolog subfamily C member 3 precursor

      See identical proteins and their annotated locations for NP_032955.2

      Status: VALIDATED

      Source sequence(s)
      AC154377, AK148270, BB618718, BE685675
      Consensus CDS
      CCDS37012.1
      UniProtKB/Swiss-Prot
      Q91YW3
      UniProtKB/TrEMBL
      Q3UFV9
      Related
      ENSMUSP00000022734.8, ENSMUST00000022734.9
      Conserved Domains (6) summary
      COG0484
      Location:392498
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:3765
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:394459
      DnaJ; DnaJ domain
      pfam00515
      Location:107137
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:36100
      TPR_11; TPR repeat
      pfam14559
      Location:318382
      TPR_19; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      119175344..119219114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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