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    Prpf19 pre-mRNA processing factor 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246216, updated on 12-Jan-2022

    Summary

    Official Symbol
    Prpf19provided by RGD
    Official Full Name
    pre-mRNA processing factor 19provided by RGD
    Primary source
    RGD:708496
    See related
    Ensembl:ENSRNOG00000020897
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prp19
    Summary
    Predicted to enable identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in positive regulation of astrocyte differentiation. Acts upstream of or within positive regulation of neuron differentiation. Located in nucleus. Orthologous to human PRPF19 (pre-mRNA processing factor 19). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in Adrenal (RPKM 304.7), Muscle (RPKM 253.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Prpf19 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207541582..207552664)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226947065..226958147)

    Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 15 member 3 Neighboring gene transmembrane protein 132A Neighboring gene transmembrane protein 109 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene prostaglandin D2 receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC124562

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of astrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spliceosomal complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spliceosomal tri-snRNP complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Prp19 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     
    NOT part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pre-mRNA-processing factor 19
    Names
    PRP19/PSO4 homolog
    PRP19/PSO4 pre-mRNA processing factor 19 homolog
    RING-type E3 ubiquitin transferase PRP19
    neuronal differentiation-related gene protein
    NP_647549.2
    XP_006231076.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139333.3NP_647549.2  pre-mRNA-processing factor 19

      See identical proteins and their annotated locations for NP_647549.2

      Status: PROVISIONAL

      Source sequence(s)
      BC107669
      UniProtKB/Swiss-Prot
      Q9JMJ4
      Related
      ENSRNOP00000081671.1, ENSRNOT00000102359.1
      Conserved Domains (4) summary
      cd00200
      Location:223503
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:224262
      7WD40; WD40 repeat [structural motif]
      cd16656
      Location:456
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
      pfam08606
      Location:69133
      Prp19; Prp19/Pso4-like

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

      Range
      207541582..207552664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231014.4XP_006231076.1  pre-mRNA-processing factor 19 isoform X1

      See identical proteins and their annotated locations for XP_006231076.1

      Related
      ENSRNOP00000028373.7, ENSRNOT00000028373.7
      Conserved Domains (4) summary
      cd00200
      Location:242522
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:243281
      7WD40; WD40 repeat [structural motif]
      cd16656
      Location:456
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
      pfam08606
      Location:69152
      Prp19; Prp19/Pso4-like
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