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    tpcn1 two pore segment channel 1 [ Danio rerio (zebrafish) ]

    Gene ID: 567534, updated on 5-Jan-2022

    Summary

    Official Symbol
    tpcn1provided by ZNC
    Official Full Name
    two pore segment channel 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-199
    See related
    Ensembl:ENSDARG00000062362
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-125i10.5
    Summary
    Predicted to enable voltage-gated calcium channel activity. Predicted to act upstream of or within ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endosome membrane and lysosomal membrane. Orthologous to human TPCN1 (two pore segment channel 1). [provided by Alliance of Genome Resources, Nov 2021]
    Orthologs
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    Genomic context

    See tpcn1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23200957..23231224)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22697153..22727424)
    103 previous assembly Zv9 (GCF_000002035.4) 5 NC_007116.5 (24869702..24900159)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 73 Neighboring gene IQ motif containing D Neighboring gene angiotensin II receptor, type 2 Neighboring gene si:dkey-125i10.3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    two pore calcium channel protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      23200957..23231224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165220.3XP_005165277.1  two pore calcium channel protein 1 isoform X3

      UniProtKB/TrEMBL
      A2BHL7
      Related
      ENSDARP00000118062.2, ENSDART00000138123.4
      Conserved Domains (1) summary
      pfam00520
      Location:133319
      Ion_trans; Ion transport protein
    2. XM_005165219.4XP_005165276.1  two pore calcium channel protein 1 isoform X2

      Conserved Domains (1) summary
      pfam00520
      Location:139325
      Ion_trans; Ion transport protein
    3. XM_690831.8XP_695923.4  two pore calcium channel protein 1 isoform X1

      Conserved Domains (1) summary
      pfam00520
      Location:139325
      Ion_trans; Ion transport protein
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