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    Anxa2 annexin A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56611, updated on 12-Jan-2022

    Summary

    Official Symbol
    Anxa2provided by RGD
    Official Full Name
    annexin A2provided by RGD
    Primary source
    RGD:621170
    See related
    Ensembl:ENSRNOG00000010362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ANX2
    Summary
    Enables bone sialoprotein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of fibroblast proliferation; protein localization to plasma membrane; and response to thyroid hormone. Located in several cellular components, including macropinosome; membrane raft; and ruffle. Part of protein-containing complex. Biomarker of hyperthyroidism; hypothyroidism; and renal cell carcinoma. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in Lung (RPKM 1285.6), Heart (RPKM 657.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Anxa2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70105268..70141663)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (75687134..75723589)

    Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene RAR-related orphan receptor A Neighboring gene uncharacterized LOC120094342 Neighboring gene interactor of little elongation complex ELL subunit 2 Neighboring gene uncharacterized LOC103693133 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables bone sialoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phospholipase A2 inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phospholipase A2 inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables virion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in body fluid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane raft assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of low-density lipoprotein particle receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoclast development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of low-density lipoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vacuole organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fibrinolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to thyroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in vesicle budding from membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of AnxA2-p11 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PCSK9-AnxA2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Schmidt-Lanterman incisure ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in macropinosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath adaxonal region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of plasma membrane protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    annexin A2
    Names
    PAP-IV
    annexin-2
    calpactin I heavy chain
    calpactin-1 heavy chain
    chromobindin-8
    lipocortin II
    p36
    placental anticoagulant protein IV
    protein I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019905.1NP_063970.1  annexin A2

      See identical proteins and their annotated locations for NP_063970.1

      Status: PROVISIONAL

      Source sequence(s)
      X66871
      UniProtKB/Swiss-Prot
      Q07936
      Related
      ENSRNOP00000038428.6, ENSRNOT00000038677.6
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

      Range
      70105268..70141663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082021.1XP_038937949.1  annexin A2 isoform X1

      Related
      ENSRNOP00000084769.1, ENSRNOT00000114456.1
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin
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