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    Atp6ap1 ATPase H+ transporting accessory protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83615, updated on 12-Jan-2022

    Summary

    Official Symbol
    Atp6ap1provided by RGD
    Official Full Name
    ATPase H+ transporting accessory protein 1provided by RGD
    Primary source
    RGD:620423
    See related
    Ensembl:ENSRNOG00000054352
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C7-1; Atp6s1
    Summary
    Predicted to enable small GTPase binding activity. Involved in aging and cell death. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be integral component of membrane. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in Brain (RPKM 817.8), Adrenal (RPKM 570.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atp6ap1 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (152079954..152087034)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156407973..156415053, complement)

    Chromosome X - NC_051356.1Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 1-like 1 Neighboring gene small nuclear ribonucleoprotein G-like Neighboring gene tafazzin, phospholipid-lysophospholipid transacylase Neighboring gene GDP dissociation inhibitor 1 Neighboring gene family with sequence similarity 50, member A Neighboring gene transfer RNA alanine (anticodon AGC)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to increased oxygen levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to increased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to increased oxygen levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endosome to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endosome to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of organelle localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of organelle localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in osteoclast development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoclast development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoclast development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pH reduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pH reduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoclast development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoclast development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in proton-transporting V-type ATPase complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase subunit S1
    Names
    ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1
    ATPase, H+ transporting, lysosomal accessory protein 1
    V-ATPase Ac45 subunit
    V-ATPase S1 accessory protein
    V-ATPase subunit S1
    vacuolar proton pump subunit S1
    NP_113973.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031785.2NP_113973.2  V-type proton ATPase subunit S1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JACYVU010000491
      Related
      ENSRNOP00000069530.1, ENSRNOT00000081914.2
      Conserved Domains (1) summary
      pfam05827
      Location:315461
      ATP-synt_S1; Vacuolar ATP synthase subunit S1 (ATP6S1)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051356.1 Reference mRatBN7.2 Primary Assembly

      Range
      152079954..152087034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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