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    Bsn bassoon [ Mus musculus (house mouse) ]

    Gene ID: 12217, updated on 25-Nov-2021

    Summary

    Official Symbol
    Bsnprovided by MGI
    Official Full Name
    bassoonprovided by MGI
    Primary source
    MGI:MGI:1277955
    See related
    Ensembl:ENSMUSG00000032589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in cortex adult (RPKM 15.2), frontal lobe adult (RPKM 14.2) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bsn in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107973221..108067618, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108096022..108190419, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107998353..108092714, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene microRNA 7088 Neighboring gene macrophage stimulating 1 (hepatocyte growth factor-like) Neighboring gene acylpeptide hydrolase Neighboring gene RIKEN cDNA 4930447F24 gene Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene dystroglycan 1 Neighboring gene nicolin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein light chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of presynaptic active zone IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in axo-dendritic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynapse to nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic active zone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in presynaptic active zone assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein localization to synapse IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of synaptic vesicle cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in GABA-ergic synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoskeleton of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton of presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in piccolo-bassoon transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribbon synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein bassoon
    Names
    presynaptic cytomatrix protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007567.2NP_031593.2  protein bassoon

      See identical proteins and their annotated locations for NP_031593.2

      Status: VALIDATED

      Source sequence(s)
      AC137678, AI836567, AK129141, AK135719, BY742476
      Consensus CDS
      CCDS23517.1
      UniProtKB/Swiss-Prot
      O88737
      UniProtKB/TrEMBL
      Q3UXD6
      Related
      ENSMUSP00000035208.7, ENSMUST00000035208.14
      Conserved Domains (8) summary
      PHA03247
      Location:34923906
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:13911625
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK12323
      Location:545759
      PRK12323; DNA polymerase III subunit gamma/tau
      PRK14971
      Location:193347
      PRK14971; DNA polymerase III subunit gamma/tau
      cd15772
      Location:462525
      FYVE2_BSN_PCLO; FYVE-related domain 2 found in protein bassoon and piccolo
      cd15773
      Location:162225
      FYVE1_BSN; FYVE-related domain 1 found in protein bassoon
      pfam05109
      Location:30353365
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam17380
      Location:23612432
      DUF5401; Family of unknown function (DUF5401)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107973221..108067618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511634.4XP_006511697.1  protein bassoon isoform X1

      See identical proteins and their annotated locations for XP_006511697.1

      UniProtKB/Swiss-Prot
      O88737
      Conserved Domains (8) summary
      PHA03247
      Location:34923906
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:13911625
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK12323
      Location:545759
      PRK12323; DNA polymerase III subunit gamma/tau
      PRK14971
      Location:193347
      PRK14971; DNA polymerase III subunit gamma/tau
      cd15772
      Location:462525
      FYVE2_BSN_PCLO; FYVE-related domain 2 found in protein bassoon and piccolo
      cd15773
      Location:162225
      FYVE1_BSN; FYVE-related domain 1 found in protein bassoon
      pfam05109
      Location:30353365
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam17380
      Location:23612432
      DUF5401; Family of unknown function (DUF5401)
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