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    Slc26a4 solute carrier family 26, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 23985, updated on 19-Jul-2021

    Summary

    Official Symbol
    Slc26a4provided by MGI
    Official Full Name
    solute carrier family 26, member 4provided by MGI
    Primary source
    MGI:MGI:1346029
    See related
    Ensembl:ENSMUSG00000020651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; pe; Pds; pendrin
    Expression
    Biased expression in kidney adult (RPKM 9.5), adrenal adult (RPKM 0.9) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc26a4 in Genome Data Viewer
    Location:
    12; 12 A2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31569813..31610054, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31519814..31560055, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (32204684..32244834, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 26, member 3 Neighboring gene Casitas B-lineage lymphoma-like 1 Neighboring gene predicted gene, 40362 Neighboring gene B cell receptor associated protein 29 Neighboring gene dihydrouridine synthase 4-like (S. cerevisiae)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables anion:anion antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables iodide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inorganic anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sulfate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pendrin
    Names
    sodium-independent chloride/iodide transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011867.4NP_035997.1  pendrin

      See identical proteins and their annotated locations for NP_035997.1

      Status: VALIDATED

      Source sequence(s)
      AC123618, CR974423
      Consensus CDS
      CCDS36429.1
      UniProtKB/Swiss-Prot
      Q9R155
      Related
      ENSMUSP00000001253.8, ENSMUST00000001253.8
      Conserved Domains (1) summary
      TIGR00815
      Location:70725
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      31569813..31610054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515092.5XP_006515155.1  pendrin isoform X1

      See identical proteins and their annotated locations for XP_006515155.1

      UniProtKB/Swiss-Prot
      Q9R155
      Conserved Domains (1) summary
      TIGR00815
      Location:70725
      sulP; high affinity sulphate transporter 1
    2. XM_006515091.1XP_006515154.1  pendrin isoform X1

      See identical proteins and their annotated locations for XP_006515154.1

      UniProtKB/Swiss-Prot
      Q9R155
      Conserved Domains (1) summary
      TIGR00815
      Location:70725
      sulP; high affinity sulphate transporter 1
    3. XM_017315068.3XP_017170557.1  pendrin isoform X1

      UniProtKB/Swiss-Prot
      Q9R155
      Conserved Domains (1) summary
      TIGR00815
      Location:70725
      sulP; high affinity sulphate transporter 1
    4. XM_011243870.4XP_011242172.1  pendrin isoform X2

      Conserved Domains (1) summary
      pfam00916
      Location:84421
      Sulfate_transp; Sulfate permease family

    RNA

    1. XR_003950047.1 RNA Sequence

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