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    Endou endonuclease, polyU-specific [ Mus musculus (house mouse) ]

    Gene ID: 19011, updated on 23-Jun-2021

    Summary

    Official Symbol
    Endouprovided by MGI
    Official Full Name
    endonuclease, polyU-specificprovided by MGI
    Primary source
    MGI:MGI:97746
    See related
    Ensembl:ENSMUSG00000022468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp; Pp11r; Tcl-3; Tcl-30
    Expression
    Biased expression in thymus adult (RPKM 54.3) and lung adult (RPKM 2.5) See more
    Orthologs
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    Genomic context

    See Endou in Genome Data Viewer
    Location:
    15 F1; 15 53.7 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97608896..97629286, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97711015..97731405, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (97541450..97561836, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41394 Neighboring gene RNA polymerase II associated protein 3 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene predicted gene, 33531 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3, opposite strand 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    poly(U)-specific endoribonuclease
    Names
    PP11-related protein
    T-cell-specific protein 30
    placental protein 11 related
    placental protein 11-related protein
    protein endoU
    uridylate-specific endoribonuclease
    NP_001162164.1
    NP_032928.1
    XP_006520680.2
    XP_006520681.1
    XP_017172000.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168693.1NP_001162164.1  poly(U)-specific endoribonuclease isoform 2 precursor

      See identical proteins and their annotated locations for NP_001162164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains different segments for its 5' UTR and coding region, compared to variant 1. The predicted protein (isoform 2) results from translation initiation at an upstream AUG and has a shorter N-terminus, when it is compared to isoform 1.
      Source sequence(s)
      AA119943, AC104225, AK132616
      Consensus CDS
      CCDS49712.1
      UniProtKB/Swiss-Prot
      Q3V188
      Related
      ENSMUSP00000097820.3, ENSMUST00000100249.10
      Conserved Domains (2) summary
      pfam01033
      Location:2260
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:140406
      XendoU; Endoribonuclease XendoU
    2. NM_008902.3NP_032928.1  poly(U)-specific endoribonuclease isoform 1

      See identical proteins and their annotated locations for NP_032928.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC104225
      Consensus CDS
      CCDS27783.1
      UniProtKB/Swiss-Prot
      Q3V188
      Related
      ENSMUSP00000023105.4, ENSMUST00000023105.5
      Conserved Domains (2) summary
      pfam01033
      Location:130167
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:182448
      XendoU; Endoribonuclease XendoU

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97608896..97629286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520618.2XP_006520681.1  poly(U)-specific endoribonuclease isoform X2

      Conserved Domains (2) summary
      pfam01033
      Location:644
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:124390
      XendoU; Endoribonuclease XendoU
    2. XM_006520617.4XP_006520680.2  poly(U)-specific endoribonuclease isoform X1

      Conserved Domains (2) summary
      pfam01033
      Location:4684
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:164430
      XendoU; Endoribonuclease XendoU
    3. XM_017316511.1XP_017172000.1  poly(U)-specific endoribonuclease isoform X3

      Conserved Domains (2) summary
      pfam01033
      Location:3471
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:86352
      XendoU; Endoribonuclease XendoU
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