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    Insl5 insulin-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 23919, updated on 23-Jun-2021

    Summary

    Official Symbol
    Insl5provided by MGI
    Official Full Name
    insulin-like 5provided by MGI
    Primary source
    MGI:MGI:1346085
    See related
    Ensembl:ENSMUSG00000066090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RI; RIF2
    Expression
    Biased expression in colon adult (RPKM 40.9) and thymus adult (RPKM 3.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Insl5 in Genome Data Viewer
    Location:
    4 C6; 4 47.27 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102875069..102884468, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103017872..103027271, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (102690477..102699333, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like (endophilin) interacting protein 1 Neighboring gene predicted gene 12709 Neighboring gene dynein light chain Tctex-type 5 Neighboring gene expressed sequence BB031773 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene MEIR1 treanscription regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    insulin-like peptide INSL5
    Names
    relaxin/insulin-like factor 2
    relaxin/insulin-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290648.2NP_001277577.1  insulin-like peptide INSL5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001277577.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL732543, BX004765
      Consensus CDS
      CCDS71431.1
      UniProtKB/Swiss-Prot
      Q9WUG6
      UniProtKB/TrEMBL
      A2AIY3
      Related
      ENSMUSP00000102482.3, ENSMUST00000106869.3
      Conserved Domains (1) summary
      cd04365
      Location:35145
      IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
    2. NM_011831.2NP_035961.1  insulin-like peptide INSL5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_035961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AF133817
      Consensus CDS
      CCDS18406.1
      UniProtKB/Swiss-Prot
      Q9WUG6
      Related
      ENSMUSP00000081416.6, ENSMUST00000084382.6
      Conserved Domains (1) summary
      cd04365
      Location:25135
      IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      102875069..102884468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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