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    Srm spermidine synthase [ Mus musculus (house mouse) ]

    Gene ID: 20810, updated on 23-Jun-2021

    Summary

    Official Symbol
    Srmprovided by MGI
    Official Full Name
    spermidine synthaseprovided by MGI
    Primary source
    MGI:MGI:102690
    See related
    Ensembl:ENSMUSG00000006442
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sp; SpdST; SpdSy; AA407669
    Expression
    Ubiquitous expression in ovary adult (RPKM 69.9), limb E14.5 (RPKM 62.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Srm in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148675970..148679076)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148591513..148594619)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (147965622..147968728)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene predicted gene, 23318 Neighboring gene exosome component 10 Neighboring gene mannan-binding lectin serine peptidase 2 Neighboring gene TAR DNA binding protein Neighboring gene predicted gene 572

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the Srm gene: The Srm gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs from Annotation Pipeline: 366 organisms have orthologs with human gene Srm
    • Orthologs

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables spermidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables spermidine synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in polyamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in polyamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spermidine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    spermidine synthase
    Names
    putrescine aminopropyltransferase
    NP_033298.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009272.4NP_033298.1  spermidine synthase

      See identical proteins and their annotated locations for NP_033298.1

      Status: PROVISIONAL

      Source sequence(s)
      AL606969
      Consensus CDS
      CCDS18940.1
      UniProtKB/Swiss-Prot
      Q64674
      UniProtKB/TrEMBL
      Q543H0
      Related
      ENSMUSP00000006611.9, ENSMUST00000006611.9
      Conserved Domains (1) summary
      PLN02366
      Location:8298
      PLN02366; spermidine synthase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148675970..148679076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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