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    Amot angiomotin [ Mus musculus (house mouse) ]

    Gene ID: 27494, updated on 23-Jun-2021

    Summary

    Official Symbol
    Amotprovided by MGI
    Official Full Name
    angiomotinprovided by MGI
    Primary source
    MGI:MGI:108440
    See related
    Ensembl:ENSMUSG00000041688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; Sii6; CAG-2; D0Kis; D0Kist1
    Expression
    Broad expression in limb E14.5 (RPKM 14.2), genital fat pad adult (RPKM 12.4) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Amot in Genome Data Viewer
    Location:
    X; X F2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (144229420..144288962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (145446424..145505966, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (141880967..141921589, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene lipoma HMGIC fusion partner-like 1 Neighboring gene prefoldin 5 pseudogene Neighboring gene predicted gene 6446

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA1071, E230009N18Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables angiostatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of cell polarity involved in ameboidal cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within establishment of cell polarity involved in ameboidal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of small GTPase mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290274.1NP_001277203.1  angiomotin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and it's 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL807753
      UniProtKB/Swiss-Prot
      Q8VHG2
      Conserved Domains (2) summary
      pfam12240
      Location:578781
      Angiomotin_C; Angiomotin C terminal
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_153319.3NP_695231.3  angiomotin isoform 1

      See identical proteins and their annotated locations for NP_695231.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI854771, AK129277, AL807753
      Consensus CDS
      CCDS72443.1
      UniProtKB/Swiss-Prot
      Q8VHG2
      Related
      ENSMUSP00000108455.3, ENSMUST00000112836.9
      Conserved Domains (4) summary
      PRK05641
      Location:10171049
      PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
      PRK07764
      Location:10141098
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam02463
      Location:418669
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam12240
      Location:578781
      Angiomotin_C; Angiomotin C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      144229420..144288962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251360.1XP_030107220.1  angiomotin isoform X4

      Related
      ENSMUSP00000108454.2, ENSMUST00000112835.8
      Conserved Domains (4) summary
      COG1196
      Location:19275
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK05641
      Location:628660
      PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
      PRK07764
      Location:625709
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam12240
      Location:189392
      Angiomotin_C; Angiomotin C terminal
    2. XM_011247828.3XP_011246130.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_011246130.1

      UniProtKB/Swiss-Prot
      Q8VHG2
      Conserved Domains (4) summary
      PRK05641
      Location:10171049
      PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
      PRK07764
      Location:10141098
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam02463
      Location:418669
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam12240
      Location:578781
      Angiomotin_C; Angiomotin C terminal
    3. XM_006528864.4XP_006528927.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006528927.1

      UniProtKB/Swiss-Prot
      Q8VHG2
      Conserved Domains (4) summary
      PRK05641
      Location:10171049
      PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
      PRK07764
      Location:10141098
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam02463
      Location:418669
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam12240
      Location:578781
      Angiomotin_C; Angiomotin C terminal
    4. XM_030251359.2XP_030107219.1  angiomotin isoform X2

      Conserved Domains (4) summary
      COG1196
      Location:101398
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK05641
      Location:751783
      PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
      PRK07764
      Location:748832
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam12240
      Location:312515
      Angiomotin_C; Angiomotin C terminal
    5. XM_006528867.5XP_006528930.1  angiomotin isoform X3

      Conserved Domains (4) summary
      COG1196
      Location:78375
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK05641
      Location:728760
      PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
      PRK07764
      Location:725809
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam12240
      Location:289492
      Angiomotin_C; Angiomotin C terminal
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