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    Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [ Mus musculus (house mouse) ]

    Gene ID: 11421, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aceprovided by MGI
    Official Full Name
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 1provided by MGI
    Primary source
    MGI:MGI:87874
    See related
    Ensembl:ENSMUSG00000020681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD143; AW208573
    Expression
    Biased expression in lung adult (RPKM 304.6), duodenum adult (RPKM 225.6) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ace in Genome Data Viewer
    Location:
    11 E1; 11 68.84 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105858774..105880790)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105967948..105989964)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (105829261..105851259)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene predicted gene, 53650 Neighboring gene cytochrome b-561 Neighboring gene predicted gene 11651 Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117827

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables bradykinin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables exopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallodipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidyl-dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidyl-dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tripeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis involved in coronary vascular morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in animal organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bradykinin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell proliferation in bone marrow IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hormone catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hormone catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gap junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neutrophil mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-cysteine S-nitrosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in posttranscriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of angiotensin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    angiotensin-converting enzyme
    Names
    dipeptidyl carboxypeptidase I
    dipeptidyl peptidase
    kininase II
    NP_001268748.1
    NP_033728.1
    NP_997507.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281819.2NP_001268748.1  angiotensin-converting enzyme isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL596246, AL731865
      UniProtKB/TrEMBL
      Q3TU20
      Related
      ENSMUSP00000119826.2, ENSMUST00000132280.8
      Conserved Domains (1) summary
      pfam01401
      Location:6491226
      Peptidase_M2; Angiotensin-converting enzyme
    2. NM_009598.3NP_033728.1  angiotensin-converting enzyme isoform 2 precursor

      See identical proteins and their annotated locations for NP_033728.1

      Status: VALIDATED

      Source sequence(s)
      AL596246, AL731865
      Consensus CDS
      CCDS25544.1
      UniProtKB/Swiss-Prot
      P09470
      Related
      ENSMUSP00000001964.8, ENSMUST00000001964.8
      Conserved Domains (1) summary
      pfam01401
      Location:69646
      Peptidase_M2; Angiotensin-converting enzyme
    3. NM_207624.6NP_997507.1  angiotensin-converting enzyme isoform 1 precursor

      See identical proteins and their annotated locations for NP_997507.1

      Status: VALIDATED

      Source sequence(s)
      AL596246, AL731865
      Consensus CDS
      CCDS25543.1
      UniProtKB/Swiss-Prot
      P09470
      UniProtKB/TrEMBL
      Q3TU20
      Related
      ENSMUSP00000001963.8, ENSMUST00000001963.14
      Conserved Domains (1) summary
      pfam01401
      Location:6491226
      Peptidase_M2; Angiotensin-converting enzyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105858774..105880790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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