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    Asic1 acid-sensing (proton-gated) ion channel 1 [ Mus musculus (house mouse) ]

    Gene ID: 11419, updated on 5-Jul-2021

    Summary

    Official Symbol
    Asic1provided by MGI
    Official Full Name
    acid-sensing (proton-gated) ion channel 1provided by MGI
    Primary source
    MGI:MGI:1194915
    See related
    Ensembl:ENSMUSG00000023017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; AS; Acc; BNa; ASIC; Accn2; BNaC2; ASIC1a; AI843610; B530003N02Rik
    Expression
    Biased expression in whole brain E14.5 (RPKM 11.2), CNS E18 (RPKM 10.4) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Asic1 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99568090..99599011)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99670197..99701130)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99501149..99531559)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rac GTPase-activating protein 1 Neighboring gene predicted gene, 34880 Neighboring gene predicted gene, 34939 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Neighboring gene ribosomal protein S27 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acid-sensing ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables acid-sensing ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acid-sensing ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inorganic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion gated channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ion gated channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cation transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inorganic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to acidic pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of sour taste ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acid-sensing ion channel 1
    Names
    amiloride-sensitive cation channel 2, neuronal
    brain sodium channel 2
    degenerin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289791.2NP_001276720.1  acid-sensing ion channel 1 isoform 2

      See identical proteins and their annotated locations for NP_001276720.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC134548
      Consensus CDS
      CCDS88841.1
      UniProtKB/Swiss-Prot
      Q6NXK8
      Related
      ENSMUSP00000154379.2, ENSMUST00000228185.2
      Conserved Domains (1) summary
      cl02990
      Location:63541
      ASC; Amiloride-sensitive sodium channel
    2. NM_009597.2NP_033727.1  acid-sensing ion channel 1 isoform 1

      See identical proteins and their annotated locations for NP_033727.1

      Status: VALIDATED

      Source sequence(s)
      AI850572, BC067025, CB527867
      Consensus CDS
      CCDS27826.1
      UniProtKB/Swiss-Prot
      Q6NXK8
      Related
      ENSMUSP00000023758.8, ENSMUST00000023758.9
      Conserved Domains (1) summary
      TIGR00859
      Location:19508
      ENaC; sodium channel transporter

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99568090..99599011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520297.5XP_006520360.1  acid-sensing ion channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006520360.1

      Conserved Domains (1) summary
      TIGR00859
      Location:19509
      ENaC; sodium channel transporter
    2. XM_006520298.4XP_006520361.1  acid-sensing ion channel 1 isoform X1

      See identical proteins and their annotated locations for XP_006520361.1

      Conserved Domains (1) summary
      TIGR00859
      Location:19509
      ENaC; sodium channel transporter
    3. XM_036159074.1XP_036014967.1  acid-sensing ion channel 1 isoform X2

      Conserved Domains (1) summary
      TIGR00859
      Location:19508
      ENaC; sodium channel transporter
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