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    Asic2 acid-sensing (proton-gated) ion channel 2 [ Mus musculus (house mouse) ]

    Gene ID: 11418, updated on 23-Jun-2021

    Summary

    Official Symbol
    Asic2provided by MGI
    Official Full Name
    acid-sensing (proton-gated) ion channel 2provided by MGI
    Primary source
    MGI:MGI:1100867
    See related
    Ensembl:ENSMUSG00000020704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acc; BNC; BNa; BNC1; Mdeg; ACIC2; Accn1; BNaC1; BNaC1a
    Expression
    Biased expression in frontal lobe adult (RPKM 10.0), ovary adult (RPKM 9.0) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Asic2 in Genome Data Viewer
    Location:
    11 B5; 11 48.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80770989..81859222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80880163..81968396, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (80693667..81781898, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930507D10 gene Neighboring gene sperm acrosome associated 3 Neighboring gene predicted gene, 51909 Neighboring gene predicted gene 11416 Neighboring gene predicted gene, 51910 Neighboring gene predicted gene, 42084 Neighboring gene RIKEN cDNA 1700071K01 gene Neighboring gene predicted gene 11418 Neighboring gene RIKEN cDNA 5530401A14 gene Neighboring gene predicted gene, 46254 Neighboring gene predicted gene 11419 Neighboring gene predicted gene, 31522 Neighboring gene chemokine (C-C motif) ligand 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion gated channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ion gated channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ligand-gated sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cation transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to acidic pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of sour taste ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    acid-sensing ion channel 2
    Names
    amiloride-sensitive brain sodium channel
    amiloride-sensitive cation channel 1, neuronal (degenerin)
    brain sodium channel 1
    degenerin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034013.2NP_001029185.1  acid-sensing ion channel 2 isoform MDEG1

      See identical proteins and their annotated locations for NP_001029185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MDEG1) has an alternate 5' terminal exon including the 5' UTR and 5' coding region, compared to variant MDEG2. The resulting isoform (MDEG1) is shorter and has a distinct N-terminus, compared to isoform MDEG2.
      Source sequence(s)
      AK134778, AL645842
      Consensus CDS
      CCDS36243.1
      UniProtKB/Swiss-Prot
      Q925H0
      UniProtKB/TrEMBL
      Q3UYD3
      Related
      ENSMUSP00000067095.7, ENSMUST00000066197.7
      Conserved Domains (1) summary
      cl02990
      Location:18506
      ASC; Amiloride-sensitive sodium channel
    2. NM_007384.3NP_031410.1  acid-sensing ion channel 2 isoform MDEG2

      See identical proteins and their annotated locations for NP_031410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (MDEG2) is the longer transcript and encodes the longer isoform (MDEG2).
      Source sequence(s)
      AL645626, BB342826, BC138530, CJ282964
      Consensus CDS
      CCDS25137.1
      UniProtKB/Swiss-Prot
      Q925H0
      UniProtKB/TrEMBL
      B2RRQ1
      Related
      ENSMUSP00000021045.7, ENSMUST00000021045.13
      Conserved Domains (1) summary
      TIGR00859
      Location:64557
      ENaC; sodium channel transporter

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      80770989..81859222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531996.5XP_006532059.1  acid-sensing ion channel 2 isoform X1

      Conserved Domains (1) summary
      cl02990
      Location:64590
      ASC; Amiloride-sensitive sodium channel
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