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    Acads acyl-Coenzyme A dehydrogenase, short chain [ Mus musculus (house mouse) ]

    Gene ID: 11409, updated on 23-Jun-2021

    Summary

    Official Symbol
    Acadsprovided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase, short chainprovided by MGI
    Primary source
    MGI:MGI:87868
    See related
    Ensembl:ENSMUSG00000029545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SC; Bcd1; Hdlq; SCAD; Bcd-1; Hdlq8; AI196007
    Summary
    This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in colon adult (RPKM 134.5), adrenal adult (RPKM 130.8) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Acads in Genome Data Viewer
    Location:
    5 55.99 cM; 5 F
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115248358..115257405, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115110299..115119346, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (115560308..115569322, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene signal peptide peptidase 3 Neighboring gene predicted gene, 54336 Neighboring gene ribosomal protein L37, retrotransposed Neighboring gene unc-119 lipid binding chaperone B Neighboring gene malectin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Phenotypes

    Associated conditions

    Description Tests
    HDL QTL 8
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables butyryl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables butyryl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in butyrate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in butyrate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    short-chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    butyryl-CoA dehydrogenase
    NP_031409.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007383.3NP_031409.2  short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031409.2

      Status: REVIEWED

      Source sequence(s)
      AK169428, BE993251, BY077302
      Consensus CDS
      CCDS19579.1
      UniProtKB/Swiss-Prot
      Q07417
      Related
      ENSMUSP00000031524.8, ENSMUST00000031524.11
      Conserved Domains (1) summary
      cd01158
      Location:36408
      SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115248358..115257405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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