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    Acadvl acyl-Coenzyme A dehydrogenase, very long chain [ Mus musculus (house mouse) ]

    Gene ID: 11370, updated on 23-Jun-2021

    Summary

    Official Symbol
    Acadvlprovided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase, very long chainprovided by MGI
    Primary source
    MGI:MGI:895149
    See related
    Ensembl:ENSMUSG00000018574
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VL; vlcad
    Summary
    This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in heart adult (RPKM 185.6), liver E18 (RPKM 80.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Acadvl in Genome Data Viewer
    Location:
    11 B3; 11 42.96 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69901009..69906254, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70010183..70015428, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69823694..69828909, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 23 Neighboring gene dishevelled segment polarity protein 2 Neighboring gene microRNA 324 Neighboring gene discs large MAGUK scaffold protein 4 Neighboring gene asialoglycoprotein receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain-acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    enables very-long-chain-acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables very-long-chain-acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extrinsic component of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    very long-chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    MVLCAD
    NP_059062.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017366.3NP_059062.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_059062.1

      Status: REVIEWED

      Source sequence(s)
      AI843782, AK076037, AU067294
      Consensus CDS
      CCDS24931.1
      UniProtKB/Swiss-Prot
      P50544
      Related
      ENSMUSP00000099634.4, ENSMUST00000102574.10
      Conserved Domains (2) summary
      cd01161
      Location:73482
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:95474
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69901009..69906254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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