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    Acadl acyl-Coenzyme A dehydrogenase, long-chain [ Mus musculus (house mouse) ]

    Gene ID: 11363, updated on 23-Jun-2021

    Summary

    Official Symbol
    Acadlprovided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase, long-chainprovided by MGI
    Primary source
    MGI:MGI:87866
    See related
    Ensembl:ENSMUSG00000026003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LC; LCAD; C79855; AA960361; AU018452
    Summary
    This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in heart adult (RPKM 89.2), liver E18 (RPKM 50.6) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Acadl in Genome Data Viewer
    Location:
    1 C3; 1 33.64 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66869998..66902468, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66830839..66863309, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (66877427..66909841, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene predicted gene, 46093 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene predicted gene 15793 Neighboring gene predicted gene, 27934 Neighboring gene predicted gene, 25832 Neighboring gene myosin, light polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain-acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables long-chain-acyl-CoA dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables long-chain-acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    enables palmitoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables palmitoyl-CoA oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in carnitine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carnitine metabolic process, CoA-linked IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in carnitine metabolic process, CoA-linked IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in long-chain fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in temperature homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    long-chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    acetyl-Coenzyme A dehydrogenase, long-chain
    NP_031407.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007381.4NP_031407.2  long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031407.2

      Status: REVIEWED

      Source sequence(s)
      AC124389, AK005140, AK151845
      Consensus CDS
      CCDS15023.1
      UniProtKB/Swiss-Prot
      P51174
      UniProtKB/TrEMBL
      A0A0R4J083
      Related
      ENSMUSP00000027153.6, ENSMUST00000027153.6
      Conserved Domains (2) summary
      cd01160
      Location:56427
      LCAD; Long chain acyl-CoA dehydrogenase
      COG1960
      Location:53427
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      66869998..66902468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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