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    Aatk apoptosis-associated tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 11302, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aatkprovided by MGI
    Official Full Name
    apoptosis-associated tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:1197518
    See related
    Ensembl:ENSMUSG00000025375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AATY; AATYK; aatyk1; mKIAA0641
    Expression
    Broad expression in cerebellum adult (RPKM 51.8), cortex adult (RPKM 38.4) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Aatk in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119898137..119938009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120007311..120047183, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (119868627..119908029, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567883 Neighboring gene predicted gene 11767 Neighboring gene brain-specific angiogenesis inhibitor 1-associated protein 2 Neighboring gene microRNA 3065 Neighboring gene microRNA 338 Neighboring gene centrosomal protein 131 Neighboring gene TEPSIN, adaptor related protein complex 4 accessory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase LMTK1
    Names
    apoptosis-associated tyrosine kinase 1B
    brain apoptosis-associated tyrosine kinase
    lemur tyrosine kinase 1
    NP_001185714.1
    NP_001185716.1
    NP_001364432.1
    NP_031403.2
    XP_006532054.1
    XP_006532055.1
    XP_006532056.1
    XP_006532057.1
    XP_036012123.1
    XP_036012124.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198785.1NP_001185714.1  serine/threonine-protein kinase LMTK1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an in-frame upstream start codon compared to variant 1. This variant encodes a protein (isoform 2) with a longer N-terminus than isoform 1.
      Source sequence(s)
      AB288871, BC042837, BC080846
      Consensus CDS
      CCDS56826.1
      UniProtKB/Swiss-Prot
      Q80YE4
      UniProtKB/TrEMBL
      B1AZF3
      Related
      ENSMUSP00000067181.4, ENSMUST00000064307.10
      Conserved Domains (3) summary
      smart00221
      Location:138405
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:137407
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:828880
      DUF3676; Protein of unknown function (DUF3676)
    2. NM_001198787.1NP_001185716.1  serine/threonine-protein kinase LMTK1 isoform 1

      See identical proteins and their annotated locations for NP_001185716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant, and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK036705, BC080846
      Consensus CDS
      CCDS25725.1
      UniProtKB/Swiss-Prot
      Q80YE4
      UniProtKB/TrEMBL
      B1AZF9
      Related
      ENSMUSP00000099308.2, ENSMUST00000103019.2
      Conserved Domains (3) summary
      smart00221
      Location:81348
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:80350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:771823
      DUF3676; Protein of unknown function (DUF3676)
    3. NM_001377503.1NP_001364432.1  serine/threonine-protein kinase LMTK1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL953913
      Conserved Domains (2) summary
      PHA03307
      Location:473904
      PHA03307; transcriptional regulator ICP4; Provisional
      cl21453
      Location:1230
      PKc_like; Protein Kinases, catalytic domain
    4. NM_007377.4NP_031403.2  serine/threonine-protein kinase LMTK1 isoform 1

      See identical proteins and their annotated locations for NP_031403.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      BC042837, BC080846
      Consensus CDS
      CCDS25725.1
      UniProtKB/Swiss-Prot
      Q80YE4
      UniProtKB/TrEMBL
      B1AZF9
      Related
      ENSMUSP00000099309.2, ENSMUST00000103020.8
      Conserved Domains (3) summary
      smart00221
      Location:81348
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:80350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:771823
      DUF3676; Protein of unknown function (DUF3676)

    RNA

    1. NR_165305.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953913
    2. NR_165306.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953913

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119898137..119938009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531991.3XP_006532054.1  serine/threonine-protein kinase LMTK1 isoform X1

      Conserved Domains (2) summary
      PHA03307
      Location:6501081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:137407
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    2. XM_006531993.3XP_006532056.1  serine/threonine-protein kinase LMTK1 isoform X4

      See identical proteins and their annotated locations for XP_006532056.1

      Related
      ENSMUST00000150730.8
      Conserved Domains (2) summary
      PHA03307
      Location:5931024
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:80350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    3. XM_006531994.4XP_006532057.1  serine/threonine-protein kinase LMTK1 isoform X4

      See identical proteins and their annotated locations for XP_006532057.1

      Conserved Domains (2) summary
      PHA03307
      Location:5931024
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:80350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    4. XM_006531992.5XP_006532055.1  serine/threonine-protein kinase LMTK1 isoform X2

      Conserved Domains (2) summary
      PHA03307
      Location:6011032
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:88358
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    5. XM_036156230.1XP_036012123.1  serine/threonine-protein kinase LMTK1 isoform X3

      Conserved Domains (2) summary
      PHA03307
      Location:6011032
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:88358
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    6. XM_036156231.1XP_036012124.1  serine/threonine-protein kinase LMTK1 isoform X5

      Related
      ENSMUST00000142959.2
      Conserved Domains (1) summary
      PHA03307
      Location:240671
      PHA03307; transcriptional regulator ICP4; Provisional

    RNA

    1. XR_003949229.1 RNA Sequence

    2. XR_004936683.1 RNA Sequence

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