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    Wfdc17 WAP four-disulfide core domain 17 [ Mus musculus (house mouse) ]

    Gene ID: 100034251, updated on 23-Jun-2021

    Summary

    Official Symbol
    Wfdc17provided by MGI
    Official Full Name
    WAP four-disulfide core domain 17provided by MGI
    Primary source
    MGI:MGI:3649773
    See related
    Ensembl:ENSMUSG00000069792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Amwap; Gm11428
    Expression
    Broad expression in bladder adult (RPKM 10.5), mammary gland adult (RPKM 8.0) and 15 other tissues See more
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    Genomic context

    See Wfdc17 in Genome Data Viewer
    Location:
    11 C; 11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83594882..83597095)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83704056..83706269)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (83517558..83519771)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11432 Neighboring gene predicted gene 11430 Neighboring gene WAP four-disulfide core domain 18 Neighboring gene WAP four-disulfide core domain 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    activated macrophage/microglia WAP domain protein
    Names
    extracellular proteinase inhibitor family member

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081957.1NP_001075426.1  activated macrophage/microglia WAP domain protein precursor

      See identical proteins and their annotated locations for NP_001075426.1

      Status: VALIDATED

      Source sequence(s)
      BC089618, W08116
      Consensus CDS
      CCDS36257.1
      UniProtKB/TrEMBL
      Q5SSJ1
      Related
      ENSMUSP00000090511.6, ENSMUST00000092836.6
      Conserved Domains (1) summary
      cd00199
      Location:1675
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83594882..83597095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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