Format

Send to:

Choose Destination
    • Showing Current items.

    Ldlrap1 low density lipoprotein receptor adaptor protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 100017, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ldlrap1provided by MGI
    Official Full Name
    low density lipoprotein receptor adaptor protein 1provided by MGI
    Primary source
    MGI:MGI:2140175
    See related
    Ensembl:ENSMUSG00000037295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Ar; Arh; ARH2; Arh1; FHCB1; FHCB2; AA691260
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.3), lung adult (RPKM 7.8) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ldlrap1 in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134468865..134495342, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134741554..134768032, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (134301327..134323919, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 1C, member 1 Neighboring gene microRNA 6403 Neighboring gene predicted gene, 42326 Neighboring gene macoilin 1 Neighboring gene Rh blood group, D antigen

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables AP-2 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables amyloid-beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables signaling receptor complex adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid precursor protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis involved in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neurofilament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    low density lipoprotein receptor adapter protein 1
    Names
    LDL receptor adaptor protein
    autosomal recessive hypercholesterolemia protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145554.2NP_663529.2  low density lipoprotein receptor adapter protein 1

      See identical proteins and their annotated locations for NP_663529.2

      Status: VALIDATED

      Source sequence(s)
      AK148340, AK167290, BY124598, BY435601
      Consensus CDS
      CCDS51327.1
      UniProtKB/Swiss-Prot
      Q8C142
      Related
      ENSMUSP00000036749.7, ENSMUST00000037828.8
      Conserved Domains (1) summary
      cd13159
      Location:43165
      PTB_LDLRAP-mammal-like; Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) in mammals and similar proteins Phosphotyrosine-binding (PTB) PH-like fold

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134468865..134495342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538423.5XP_006538486.1  low density lipoprotein receptor adapter protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006538486.1

      UniProtKB/Swiss-Prot
      Q8C142
      Conserved Domains (1) summary
      cd13159
      Location:1121
      PTB_LDLRAP-mammal-like; Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) in mammals and similar proteins Phosphotyrosine-binding (PTB) PH-like fold
    Support Center