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ACO1 aconitate hydratase ACO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851013, updated on 12-Oct-2021

Summary

Gene symbol
ACO1
Gene description
aconitate hydratase ACO1
Primary source
SGD:S000004295
Locus tag
YLR304C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GLU1
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Genomic context

See ACO1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (735212..737548, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Neighboring gene tRNA Neighboring gene 1-phosphatidylinositol 4-kinase STT4 Neighboring gene NEDD8-conjugating protein UBC12

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ACO1 gene: The ACO1 gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aconitate hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables aconitate hydratase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables citrate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aconitate hydratase ACO1
NP_013407.1
  • Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; mutation in human homolog ACO2 is associated with dominant optic nerve atrophy; human homolog ACO2 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    735212..737548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182192.1NP_013407.1  TPA: aconitate hydratase ACO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013407.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P19414
    Conserved Domains (1) summary
    TIGR01340
    Location:41772
    aconitase_mito; aconitate hydratase, mitochondrial
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