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Mif macrophage migration inhibitory factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 81683, updated on 10-Oct-2019

Summary

Official Symbol
Mifprovided by RGD
Official Full Name
macrophage migration inhibitory factorprovided by RGD
Primary source
RGD:621163
See related
Ensembl:ENSRNOG00000006589
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
inhibits random migration of macrophages and is involved in the pathogenesis of several inflammatory diseases [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 573.4), Brain (RPKM 421.3) and 9 other tissues See more
Orthologs

Genomic context

See Mif in Genome Data Viewer
Location:
20p12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13715219..13732980)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (15885248..15886113)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 11 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene derlin 3 Neighboring gene uncharacterized LOC103690388 Neighboring gene glutathione S-transferase, theta 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC72801

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
PubMed 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
cytokine activity ISO
Inferred from Sequence Orthology
more info
PubMed 
cytokine receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
dopachrome isomerase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
dopachrome isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
phenylpyruvate tautomerase activity IEA
Inferred from Electronic Annotation
more info
 
phenylpyruvate tautomerase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protease binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
brain renin-angiotensin system IMP
Inferred from Mutant Phenotype
more info
PubMed 
carboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
cell aging ISO
Inferred from Sequence Orthology
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle development IEP
Inferred from Expression Pattern
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell aging ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of mature B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of myeloid leukocyte cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of prostaglandin secretion involved in immune response ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
protein homotrimerization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to menaquinone IEP
Inferred from Expression Pattern
more info
PubMed 
response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
skin development IEP
Inferred from Expression Pattern
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
macrophage migration inhibitory factor
Names
L-dopachrome isomerase
L-dopachrome tautomerase
glutathione-binding 13 kDa protein
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
phenylpyruvate tautomerase
NP_112313.1
XP_017457271.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031051.1NP_112313.1  macrophage migration inhibitory factor

    See identical proteins and their annotated locations for NP_112313.1

    Status: PROVISIONAL

    Source sequence(s)
    U62326
    UniProtKB/Swiss-Prot
    P30904
    UniProtKB/TrEMBL
    A0A0F7RQL3
    Related
    ENSRNOP00000008608.3, ENSRNOT00000008608.4
    Conserved Domains (1) summary
    pfam01187
    Location:2115
    MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    13715219..13732980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601782.1XP_017457271.1  macrophage migration inhibitory factor isoform X1

    UniProtKB/Swiss-Prot
    P30904
    UniProtKB/TrEMBL
    A0A0F7RQL3
    Conserved Domains (1) summary
    pfam01187
    Location:2115
    MIF; Macrophage migration inhibitory factor (MIF)

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    14283080..14283945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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