Format

Send to:

Choose Destination

Psenen presenilin enhancer gamma secretase subunit [ Mus musculus (house mouse) ]

Gene ID: 66340, updated on 6-May-2021

Summary

Official Symbol
Psenenprovided by MGI
Official Full Name
presenilin enhancer gamma secretase subunitprovided by MGI
Primary source
MGI:MGI:1913590
See related
Ensembl:ENSMUSG00000036835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pen-2; 1700023M09Rik
Expression
Ubiquitous expression in large intestine adult (RPKM 80.2), kidney adult (RPKM 63.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Psenen in Genome Data Viewer
Location:
7; 7 B1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30261290..30263052, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30561865..30563627, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31346884..31348203, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene microRNA 9769 Neighboring gene heat shock protein, alpha-crystallin-related, B6 Neighboring gene lin-37 DREAM MuvB core complex component Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 Neighboring gene IGF-like family receptor 1 Neighboring gene lysine (K)-specific methyltransferase 2B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102026

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endopeptidase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
part_of gamma-secretase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of gamma-secretase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of gamma-secretase complex ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gamma-secretase subunit PEN-2
Names
presenilin enhancer 2 homolog
presenilin enhancer protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364016.1NP_001350945.1  gamma-secretase subunit PEN-2

    Status: VALIDATED

    Source sequence(s)
    AC167970
    Consensus CDS
    CCDS21099.1
    Related
    ENSMUSP00000146469.2, ENSMUST00000208628.2
    Conserved Domains (1) summary
    pfam10251
    Location:799
    PEN-2; Presenilin enhancer-2 subunit of gamma secretase
  2. NM_001364017.1NP_001350946.1  gamma-secretase subunit PEN-2

    Status: VALIDATED

    Source sequence(s)
    AC167970, AV576632, W65052
    Consensus CDS
    CCDS21099.1
    Conserved Domains (1) summary
    pfam10251
    Location:799
    PEN-2; Presenilin enhancer-2 subunit of gamma secretase
  3. NM_025498.3NP_079774.1  gamma-secretase subunit PEN-2

    See identical proteins and their annotated locations for NP_079774.1

    Status: VALIDATED

    Source sequence(s)
    AC167970, BC081443
    Consensus CDS
    CCDS21099.1
    UniProtKB/Swiss-Prot
    Q9CQR7
    Related
    ENSMUSP00000044682.7, ENSMUST00000043898.8
    Conserved Domains (1) summary
    pfam10251
    Location:799
    PEN-2; Presenilin enhancer-2 subunit of gamma secretase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30261290..30263052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center