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gm2a GM2 ganglioside activator [ Danio rerio (zebrafish) ]

Gene ID: 550529, updated on 5-Jan-2022

Summary

Official Symbol
gm2aprovided by ZNC
Official Full Name
GM2 ganglioside activatorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-373
See related
Ensembl:ENSDARG00000088439
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110188
Summary
Predicted to enable lipid transporter activity. Predicted to be involved in ganglioside catabolic process and lipid transport. Predicted to be active in cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in GM2 gangliosidosis and GM2 gangliosidosis, AB variant. Orthologous to human GM2A (GM2 ganglioside activator). [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See gm2a in Genome Data Viewer
Location:
chromosome: 14
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (26224504..26228023)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (25927078..25930593)
103 previous assembly Zv9 (GCF_000002035.4) 14 NC_007125.5 (27233956..27237487)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene melatonin receptor type 1A like Neighboring gene FAT atypical cadherin 2 Neighboring gene ganglioside GM2 activator-like Neighboring gene coiled-coil domain containing 69

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in ganglioside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ganglioside catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017831.1NP_001017831.1  ganglioside GM2 activator precursor

    See identical proteins and their annotated locations for NP_001017831.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092784
    UniProtKB/TrEMBL
    Q568N7
    Related
    ENSDARP00000106218.1, ENSDART00000128971.2
    Conserved Domains (1) summary
    cl00274
    Location:38198
    ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    26224504..26228023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173119.4XP_005173176.1  ganglioside GM2 activator isoform X1

    Conserved Domains (1) summary
    cl00274
    Location:49209
    ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...
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