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TMPRSS2 transmembrane serine protease 2 [ Bos taurus (cattle) ]

Gene ID: 511037, updated on 2-Jul-2020

Summary

Official Symbol
TMPRSS2provided by VGNC
Official Full Name
transmembrane serine protease 2provided by VGNC
Primary source
VGNC:VGNC:36140
See related
BGD:BT22202; Ensembl:ENSBTAG00000009132
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
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Genomic context

See TMPRSS2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 1 NC_037328.1 (141711586..141758108, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 1 AC_000158.1 (143209954..143256530, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene MX dynamin like GTPase 2 Neighboring gene MX dynamin like GTPase 1 Neighboring gene keratin-associated protein 10-8-like Neighboring gene keratin-associated protein 12-2

Genomic regions, transcripts, and products

General gene information

Homology

Clone Names

  • MGC154978

General protein information

Preferred Names
transmembrane protease serine 2
Names
transmembrane protease, serine 2
NP_001075054.1
XP_005202057.1
XP_015329141.1
XP_015329143.1
XP_024835315.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081585.1NP_001075054.1  transmembrane protease serine 2

    See identical proteins and their annotated locations for NP_001075054.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133425
    UniProtKB/TrEMBL
    A2VDV7
    Related
    ENSBTAP00000012036.4, ENSBTAT00000012036.5
    Conserved Domains (3) summary
    cd00112
    Location:121146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151246
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    141711586..141758108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005202000.4XP_005202057.1  transmembrane protease serine 2 isoform X2

    See identical proteins and their annotated locations for XP_005202057.1

    UniProtKB/TrEMBL
    A2VDV7
    Conserved Domains (3) summary
    cd00112
    Location:121146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151246
    SRCR_2; Scavenger receptor cysteine-rich domain
  2. XM_024979547.1XP_024835315.1  transmembrane protease serine 2 isoform X2

    Conserved Domains (3) summary
    cd00112
    Location:121146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151246
    SRCR_2; Scavenger receptor cysteine-rich domain
  3. XM_015473657.2XP_015329143.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (4) summary
    smart00020
    Location:253482
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:121146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151246
    SRCR_2; Scavenger receptor cysteine-rich domain
  4. XM_015473655.2XP_015329141.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (4) summary
    smart00020
    Location:253482
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:121146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:151246
    SRCR_2; Scavenger receptor cysteine-rich domain
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