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TMPRSS2 transmembrane serine protease 2 [ Canis lupus familiaris (dog) ]

Gene ID: 487770, updated on 2-Oct-2021

Summary

Official Symbol
TMPRSS2provided by VGNC
Official Full Name
transmembrane serine protease 2provided by VGNC
Primary source
VGNC:VGNC:53045
See related
EnsemblRapid:ENSCAFG00845030150
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
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Genomic context

See TMPRSS2 in Genome Data Viewer
Location:
chromosome: 31
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 31 NC_051835.1 (35451094..35486696, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 31 NC_006613.4 (35087922..35123133, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 31 NC_049252.1 (35819128..35854769, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 31 NC_049291.1 (35346223..35380906, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 31 NC_049772.1 (35325381..35360709, complement)
105 previous assembly CanFam3.1 (GCF_000002285.3) 31 NC_006613.3 (35933082..35968732, complement)

Chromosome 31 - NC_051835.1Genomic Context describing neighboring genes Neighboring gene MX dynamin like GTPase 2 Neighboring gene MX dynamin like GTPase 1 Neighboring gene uncharacterized LOC119867075 Neighboring gene keratin-associated protein 10-8

Genomic regions, transcripts, and products

General gene information

Homology

General protein information

Preferred Names
transmembrane protease serine 2; LOW QUALITY PROTEIN: transmembrane protease serine 2
Names
transmembrane protease, serine 2
XP_038299489.1
XP_038299490.1
XP_038299491.1
XP_038317775.1
XP_038317776.1
XP_038317777.1
XP_038374094.1
XP_038437468.1
XP_038437469.1
XP_038437470.1
XP_038501855.1
XP_038501856.1
XP_038501857.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051835.1 Reference ROS_Cfam_1.0

    Range
    35451094..35486696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038443562.1XP_038299490.1  transmembrane protease serine 2 isoform X1

    Related
    ENSCAFP00845042057.1, ENSCAFT00845053525.1
    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
  2. XM_038443561.1XP_038299489.1  transmembrane protease serine 2 isoform X1

    Related
    ENSCAFP00845042037.1, ENSCAFT00845053504.1
    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
  3. XM_038443563.1XP_038299491.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049291.1 Alternate UMICH_Zoey_3.1

    Range
    35346223..35380906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038518166.1XP_038374094.1  LOW QUALITY PROTEIN: transmembrane protease serine 2 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049772.1 Alternate UNSW_CanFamBas_1.0

    Range
    35325381..35360709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038645928.1XP_038501856.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
  2. XM_038645927.1XP_038501855.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
  3. XM_038645929.1XP_038501857.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049252.1 Alternate UU_Cfam_GSD_1.0

    Range
    35819128..35854769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038581540.1XP_038437468.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
  2. XM_038581541.1XP_038437469.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
  3. XM_038581542.1XP_038437470.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006613.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35087922..35123133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038461848.1XP_038317776.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
  2. XM_038461847.1XP_038317775.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
  3. XM_038461849.1XP_038317777.1  transmembrane protease serine 2 isoform X1

    Conserved Domains (3) summary
    cd00112
    Location:113148
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:256487
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:153247
    SRCR_2; Scavenger receptor cysteine-rich domain
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