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GM2A GM2 ganglioside activator [ Pan troglodytes (chimpanzee) ]

Gene ID: 471705, updated on 19-Mar-2021

Summary

Official Symbol
GM2Aprovided by VGNC
Official Full Name
GM2 ganglioside activatorprovided by VGNC
Primary source
VGNC:VGNC:11953
Locus tag
CK820_G0010109
See related
Ensembl:ENSPTRG00000017431
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
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Genomic context

See GM2A in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Clint_PTRv2 (GCF_002880755.1) 5 NC_036884.1 (129431770..129448093)
104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 5 NC_006472.4 (151462317..151478638)

Chromosome 5 - NC_036884.1Genomic Context describing neighboring genes Neighboring gene annexin A6 Neighboring gene coiled-coil domain containing 69 Neighboring gene solute carrier family 36 member 2 Neighboring gene RUN domain-containing protein 1 pseudogene

Genomic regions, transcripts, and products

General gene information

Markers

Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

  1. NC_036884.1 Reference Clint_PTRv2 Primary Assembly

    Range
    129431770..129448093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_527083.6XP_527083.2  ganglioside GM2 activator

    See identical proteins and their annotated locations for XP_527083.2

    UniProtKB/TrEMBL
    H2QRT9
    Related
    ENSPTRP00000029783.4, ENSPTRT00000032239.5
    Conserved Domains (1) summary
    cd00258
    Location:32193
    GM2-AP; GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3. ...
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