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Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 399510, updated on 5-Sep-2021

Summary

Official Symbol
Map4k5provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 5provided by MGI
Primary source
MGI:MGI:1925503
See related
Ensembl:ENSMUSG00000034761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KH; GCK; KHS; GCKR; MAPKKK; MAPKKKK5; 4432415E19Rik
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.4), bladder adult (RPKM 8.2) and 28 other tissues See more
Orthologs
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Genomic context

See Map4k5 in Genome Data Viewer
Location:
12; 12 C2
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69850531..69939937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69803757..69893163, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70904744..70994150, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm122 Neighboring gene cyclin-dependent kinase-like 1 (CDC2-related kinase) Neighboring gene microRNA 681 Neighboring gene RIKEN cDNA 4930512B01 gene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 4931403G20 gene Neighboring gene atlastin GTPase 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RuvB-like protein 1 pseudogene Neighboring gene predicted gene, 52003 Neighboring gene salvador family WW domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 5
Names
MAPK/ERK kinase kinase kinase 5
MEK kinase kinase 5
MEKKK 5
NP_958927.2
XP_006516117.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201519.2NP_958927.2  mitogen-activated protein kinase kinase kinase kinase 5

    See identical proteins and their annotated locations for NP_958927.2

    Status: VALIDATED

    Source sequence(s)
    AK019468, AK032123, AK053775, AK084891, BC048173
    UniProtKB/Swiss-Prot
    Q8BPM2
    UniProtKB/TrEMBL
    Q05BG3
    Conserved Domains (3) summary
    smart00036
    Location:512827
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69850531..69939937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516054.4XP_006516117.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

    See identical proteins and their annotated locations for XP_006516117.1

    Related
    ENSMUSP00000047812.8, ENSMUST00000049239.8
    Conserved Domains (2) summary
    smart00036
    Location:512826
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
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