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Brwd3 bromodomain and WD repeat domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 382236, updated on 23-Jun-2021

Summary

Official Symbol
Brwd3provided by MGI
Official Full Name
bromodomain and WD repeat domain containing 3provided by MGI
Primary source
MGI:MGI:3029414
See related
Ensembl:ENSMUSG00000063663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Br; Brodl; Gm596; Gm10452; D030064D06Rik
Expression
Broad expression in placenta adult (RPKM 3.9), CNS E11.5 (RPKM 1.8) and 20 other tissues See more
Orthologs
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Genomic context

See Brwd3 in Genome Data Viewer
Location:
X; X D
Exon count:
41
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (107779451..107877965, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (108735845..108834362, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (105937547..106029694, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene WASP family 1 pseudogene Neighboring gene syntaxin 3 pseudogene Neighboring gene RIKEN cDNA 2810403D21 gene Neighboring gene capping protein (actin filament), gelsolin-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bromodomain and WD repeat-containing protein 3
Names
bromo domain-containing protein disrupted in leukemia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081477.2NP_001074946.1  bromodomain and WD repeat-containing protein 3

    See identical proteins and their annotated locations for NP_001074946.1

    Status: VALIDATED

    Source sequence(s)
    AL731764, BX000698
    Consensus CDS
    CCDS41100.1
    UniProtKB/Swiss-Prot
    A2AHJ4
    Related
    ENSMUSP00000123588.2, ENSMUST00000150434.8
    Conserved Domains (5) summary
    cd05529
    Location:11281240
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    COG2319
    Location:175540
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:172494
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:183220
    7WD40; WD40 repeat [structural motif]
    cl02556
    Location:12991439
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    107779451..107877965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528114.4XP_006528177.1  bromodomain and WD repeat-containing protein 3 isoform X1

    Conserved Domains (4) summary
    cd05529
    Location:11281240
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd00200
    Location:172494
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:183220
    7WD40; WD40 repeat [structural motif]
    cl02556
    Location:12991439
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
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