Format

Send to:

Choose Destination

selenow2b selenoprotein W, 2b [ Danio rerio (zebrafish) ]

Gene ID: 378438, updated on 5-Aug-2021

Summary

Official Symbol
selenow2bprovided by ZNC
Official Full Name
selenoprotein W, 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030428-2
See related
Ensembl:ENSDARG00000089936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sepw; cb696; sepw2b; zgc:123142; zgc:152839; si:dz180g5.2
Summary
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Unlike in mammals, where this protein is highly expressed in skeletal muscle, heart and brain; it is expressed in sensory organs in zebrafish. Paralogs of this gene, sepw1 and sepw2a, are found on chromosomes 5 and 3, respectively. [provided by RefSeq, Jul 2017]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See selenow2b in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (20103745..20106220, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (19954005..19956471, complement)
103 previous assembly Zv9 (GCF_000002035.4) 3 NC_007114.5 (19993030..19995496, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene upstream binding transcription factor Neighboring gene solute carrier family 4 member 1a (Diego blood group) Neighboring gene uncharacterized LOC110438598 Neighboring gene selenoprotein W, 2a Neighboring gene nerve growth factor receptor a (TNFR superfamily, member 16)

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Homology

Clone Names

  • MGC123142, MGC152839

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to selenium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194418.3NP_919399.3  selenoprotein W, 2b

    Status: REVIEWED

    Source sequence(s)
    BC124148, CK687346, DV591466, EH468996
    Related
    ENSDARP00000118513.1, ENSDART00000145285.3
    Conserved Domains (1) summary
    TIGR02174
    Location:575
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    20103745..20106220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394528.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    11570..14045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center