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Dennd1b DENN/MADD domain containing 1B [ Mus musculus (house mouse) ]

Gene ID: 329260, updated on 19-Jul-2021

Summary

Official Symbol
Dennd1bprovided by MGI
Official Full Name
DENN/MADD domain containing 1Bprovided by MGI
Primary source
MGI:MGI:2447812
See related
Ensembl:ENSMUSG00000056268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632404N19Rik; 4930467M19Rik; 6820401H01Rik; F730008N07Rik
Expression
Ubiquitous expression in placenta adult (RPKM 2.2), thymus adult (RPKM 1.6) and 28 other tissues See more
Orthologs
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Genomic context

See Dennd1b in Genome Data Viewer
Location:
1; 1 E4
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (138891447..139103781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (138963709..139176043)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (140860286..141072620)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310009B15 gene Neighboring gene RIKEN cDNA 1700019P21 gene Neighboring gene RIKEN cDNA 4930596I21 gene Neighboring gene glutathione S-transferase, mu 5 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene uncharacterized LOC118567640 Neighboring gene predicted gene 16304 Neighboring gene predicted gene, 41960 Neighboring gene crumbs family member 1, photoreceptor morphogenesis associated Neighboring gene RIKEN cDNA 4933436E23 gene Neighboring gene predicted gene, 34816

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC51484

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 2 cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DENN domain-containing protein 1B
Names
ASL1/9AS1-1 fusion
connecdenn 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166501.1NP_001159973.1  DENN domain-containing protein 1B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117623, AC138741
    Consensus CDS
    CCDS48384.1
    UniProtKB/Swiss-Prot
    Q3U1T9
    Related
    ENSMUSP00000127580.2, ENSMUST00000168527.8
    Conserved Domains (3) summary
    smart00801
    Location:303368
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92271
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:989
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  2. NM_181347.3NP_851992.1  DENN domain-containing protein 1B isoform 2

    See identical proteins and their annotated locations for NP_851992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138741, AK155727
    Consensus CDS
    CCDS35728.1
    UniProtKB/Swiss-Prot
    Q3U1T9
    Related
    ENSMUSP00000092082.4, ENSMUST00000094505.6
    Conserved Domains (2) summary
    smart00801
    Location:228293
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:17196
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    138891447..139103781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529716.5XP_006529779.1  DENN domain-containing protein 1B isoform X1

    Conserved Domains (3) summary
    smart00801
    Location:323388
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92291
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:989
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  2. XM_036165904.1XP_036021797.1  DENN domain-containing protein 1B isoform X5

    Conserved Domains (3) summary
    smart00801
    Location:240305
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92227
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:989
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  3. XM_036165909.1XP_036021802.1  DENN domain-containing protein 1B isoform X7

    Conserved Domains (3) summary
    smart00801
    Location:220285
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92207
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:989
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  4. XM_036165910.1XP_036021803.1  DENN domain-containing protein 1B isoform X8

    Conserved Domains (3) summary
    smart00801
    Location:323388
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92291
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:989
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  5. XM_036165911.1XP_036021804.1  DENN domain-containing protein 1B isoform X9

    Conserved Domains (3) summary
    smart00801
    Location:303368
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:92271
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:989
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  6. XM_036165912.1XP_036021805.1  DENN domain-containing protein 1B isoform X10

    Conserved Domains (1) summary
    pfam03455
    Location:138
    dDENN; dDENN domain
  7. XM_006529719.4XP_006529782.1  DENN domain-containing protein 1B isoform X6

    Conserved Domains (2) summary
    smart00801
    Location:225290
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:21193
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
  8. XM_006529718.4XP_006529781.1  DENN domain-containing protein 1B isoform X4

    Conserved Domains (2) summary
    smart00801
    Location:245310
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:21213
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
  9. XM_006529717.4XP_006529780.1  DENN domain-containing protein 1B isoform X2

    Conserved Domains (3) summary
    smart00801
    Location:287352
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:56255
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:753
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  10. XM_030255029.2XP_030110889.1  DENN domain-containing protein 1B isoform X3

    Conserved Domains (3) summary
    smart00801
    Location:267332
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:56235
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:753
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
  11. XM_036165915.1XP_036021808.1  DENN domain-containing protein 1B isoform X10

    Conserved Domains (1) summary
    pfam03455
    Location:138
    dDENN; dDENN domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183217.2: Suppressed sequence

    Description
    NM_183217.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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