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aco2 aconitase 2, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 322670, updated on 5-Jan-2022

Summary

Official Symbol
aco2provided by ZNC
Official Full Name
aconitase 2, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1390
See related
Ensembl:ENSDARG00000007294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb1017; wu:fa10e03; wu:fb69g04; wu:fc20c11
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including adaxial cell; heart tube; musculature system; nervous system; and pronephric duct. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See aco2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (19106571..19119154, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18984697..18997280, complement)
103 previous assembly Zv9 (GCF_000002035.4) 12 NC_007123.5 (20202853..20215436, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 2Cb Neighboring gene cold shock domain containing C2, RNA binding a Neighboring gene PHD finger protein 5A Neighboring gene TEF transcription factor, PAR bZIP family member a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aconitate hydratase, mitochondrial
NP_944590.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198908.1NP_944590.1  aconitate hydratase, mitochondrial

    See identical proteins and their annotated locations for NP_944590.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058049
    UniProtKB/TrEMBL
    Q6PEI6
    Related
    ENSDARP00000123883.2, ENSDART00000149180.3
    Conserved Domains (3) summary
    cd01584
    Location:97507
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:589737
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:47777
    aconitase_mito; aconitate hydratase, mitochondrial

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    19106571..19119154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    328446..344007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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