Format

Send to:

Choose Destination

Gm2a GM2 ganglioside activator [ Rattus norvegicus (Norway rat) ]

Gene ID: 282838, updated on 30-Sep-2021

Summary

Official Symbol
Gm2aprovided by RGD
Official Full Name
GM2 ganglioside activatorprovided by RGD
Primary source
RGD:628651
See related
EnsemblRapid:ENSRNOG00000052219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
mouse homolog is involved in sphingolipid metabolism [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 1154.8), Spleen (RPKM 598.3) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gm2a in Genome Data Viewer
Location:
10q22
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (39219221..39231756)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40438394..40450927)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene Y box protein 1 related, pseudogene 3 Neighboring gene coiled-coil domain containing 69 Neighboring gene solute carrier family 36, member 3 Neighboring gene solute carrier family 36 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to beta-N-acetylgalactosaminidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-N-acetylhexosaminidase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IC
Inferred by Curator
more info
PubMed 
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ganglioside GM2 activator
Names
GM2 ganglioside activator protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172335.2NP_758838.2  ganglioside GM2 activator precursor

    See identical proteins and their annotated locations for NP_758838.2

    Status: PROVISIONAL

    Source sequence(s)
    BC072474
    UniProtKB/TrEMBL
    Q6IN37
    Related
    ENSRNOP00000071876.2, ENSRNOT00000078910.2
    Conserved Domains (1) summary
    cl00274
    Location:39198
    ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    39219221..39231756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center