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Cntrl centriolin [ Mus musculus (house mouse) ]

Gene ID: 26920, updated on 23-Jun-2021

Summary

Official Symbol
Cntrlprovided by MGI
Official Full Name
centriolinprovided by MGI
Primary source
MGI:MGI:1889576
See related
Ensembl:ENSMUSG00000057110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cep; Ma2; Cep1; IB3/; Cep11; IB3/5; Ma2a8; Cep110; AA968343; b2b1468C; b2b1468Clo; b2b1468.1Clo; 6720467O09Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.2), thymus adult (RPKM 3.9) and 28 other tissues See more
Orthologs
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Genomic context

See Cntrl in Genome Data Viewer
Location:
2; 2 B
Exon count:
49
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34999504..35068834)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35109476..35178822)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34965012..35034342)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hemolytic complement Neighboring gene predicted gene, 39794 Neighboring gene expressed sequence AI182371 Neighboring gene RAB14, member RAS oncogene family Neighboring gene predicted gene 13605 Neighboring gene predicted gene, 52553

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
part_of centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centriolin
Names
110 kDa centrosomal protein
antigen identified by monoclonal antibody 2A8
centrosomal protein 110
centrosomal protein of 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290635.1NP_001277564.1  centriolin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several 5' and 3' exons but contains alternate 5' and 3' terminal exons, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC060146, BY032373
    Related
    ENSMUSP00000108656.3, ENSMUST00000113033.6
    Conserved Domains (1) summary
    pfam01496
    Location:173259
    V_ATPase_I; V-type ATPase 116kDa subunit family
  2. NM_001379274.1NP_001366203.1  centriolin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL773523, AL845534
    Related
    ENSMUSP00000028237.9, ENSMUST00000028237.15
    Conserved Domains (6) summary
    COG1196
    Location:4401134
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:14072216
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:100119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:127148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam06346
    Location:12391310
    Drf_FH1; Formin Homology Region 1
    cd21340
    Location:89261
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  3. NM_001379275.1NP_001366204.1  centriolin isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL773523, AL845534
    Conserved Domains (3) summary
    COG1196
    Location:2581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:8541663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686757
    Drf_FH1; Formin Homology Region 1
  4. NM_012018.2NP_036148.2  centriolin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL773523, AL845534
    Consensus CDS
    CCDS57170.2
    UniProtKB/TrEMBL
    R4GML3
    Related
    ENSMUSP00000108655.3, ENSMUST00000113032.8
    Conserved Domains (9) summary
    COG1196
    Location:4401133
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00116
    Location:86228
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam14580
    Location:83279
    LRR_9; Leucine-rich repeat
    TIGR02168
    Location:14062215
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:100119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:127148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam06346
    Location:12381309
    Drf_FH1; Formin Homology Region 1
    pfam07851
    Location:19552046
    TMPIT; TMPIT-like protein
    pfam12799
    Location:148185
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34999504..35068834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251616.2XP_030107476.1  centriolin isoform X2

    Conserved Domains (5) summary
    COG1196
    Location:287981
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:12542063
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:1841
    LRR_1; leucine-rich repeat [structural motif]
    pfam06346
    Location:10861157
    Drf_FH1; Formin Homology Region 1
    pfam14580
    Location:8126
    LRR_9; Leucine-rich repeat
  2. XM_006498069.4XP_006498132.1  centriolin isoform X1

    Conserved Domains (8) summary
    PHA02562
    Location:304538
    46; endonuclease subunit; Provisional
    COG1196
    Location:4401134
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:14072214
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:100119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:127148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam06346
    Location:12391310
    Drf_FH1; Formin Homology Region 1
    pfam14580
    Location:152279
    LRR_9; Leucine-rich repeat
    pfam12799
    Location:126167
    LRR_4; Leucine Rich repeats (2 copies)
  3. XM_036162232.1XP_036018125.1  centriolin isoform X3

    Conserved Domains (6) summary
    COG1196
    Location:4401134
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:14072083
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:100119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:127148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam06346
    Location:12391310
    Drf_FH1; Formin Homology Region 1
    cd21340
    Location:89261
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  4. XM_030251617.2XP_030107477.1  centriolin isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:44738
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:10111820
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:843914
    Drf_FH1; Formin Homology Region 1
  5. XM_036162235.1XP_036018128.1  centriolin isoform X8

    Conserved Domains (3) summary
    COG1196
    Location:2580
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:8531660
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:685756
    Drf_FH1; Formin Homology Region 1
  6. XM_030251620.2XP_030107480.1  centriolin isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:2581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:8541663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686757
    Drf_FH1; Formin Homology Region 1
  7. XM_006498073.5XP_006498136.1  centriolin isoform X5

    See identical proteins and their annotated locations for XP_006498136.1

    Conserved Domains (3) summary
    COG1196
    Location:2581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:8541663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686757
    Drf_FH1; Formin Homology Region 1
  8. XM_006498074.5XP_006498137.1  centriolin isoform X5

    See identical proteins and their annotated locations for XP_006498137.1

    Conserved Domains (3) summary
    COG1196
    Location:2581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:8541663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686757
    Drf_FH1; Formin Homology Region 1
  9. XM_036162233.1XP_036018126.1  centriolin isoform X6

    Related
    ENSMUSP00000108660.4, ENSMUST00000113037.10
    Conserved Domains (3) summary
    COG1196
    Location:2580
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:8531662
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:685756
    Drf_FH1; Formin Homology Region 1
  10. XM_006498075.5XP_006498138.1  centriolin isoform X5

    See identical proteins and their annotated locations for XP_006498138.1

    Conserved Domains (3) summary
    COG1196
    Location:2581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:8541663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686757
    Drf_FH1; Formin Homology Region 1
  11. XM_036162234.1XP_036018127.1  centriolin isoform X7

    Conserved Domains (3) summary
    COG1196
    Location:2581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:8541661
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686757
    Drf_FH1; Formin Homology Region 1

RNA

  1. XR_004940615.1 RNA Sequence

  2. XR_004940616.1 RNA Sequence

  3. XR_004940618.1 RNA Sequence

  4. XR_004940617.1 RNA Sequence

  5. XR_004940619.1 RNA Sequence

  6. XR_866015.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030000.2: Suppressed sequence

    Description
    NM_030000.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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