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Lyz2 lysozyme 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25211, updated on 30-Sep-2021

Summary

Official Symbol
Lyz2provided by RGD
Official Full Name
lysozyme 2provided by RGD
Primary source
RGD:3026
See related
EnsemblRapid:ENSRNOG00000005825
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lyz; Lysz; Lyz1
Summary
widely expressed; may mediate analgesic, anti-inflammatory, hemostatic, anti-allergy, anticancer, |and antibiotic functions [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 51113.8) and Spleen (RPKM 4301.1) See more
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Genomic context

See Lyz2 in Genome Data Viewer
Location:
7q22
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52906810..52912154, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (60335968..60341264, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 9530003J23 Neighboring gene lysozyme C type 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene cleavage and polyadenylation specific factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysozyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
 
enables lysozyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lysozyme activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cytolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
involved_in retina homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi cis cisterna IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in rough endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lysozyme C-1
Names
1,4-beta-N-acetylmuramidase C
NP_036903.2
XP_038934368.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012771.3NP_036903.2  lysozyme C-1 precursor

    See identical proteins and their annotated locations for NP_036903.2

    Status: PROVISIONAL

    Source sequence(s)
    BC058490
    UniProtKB/TrEMBL
    Q6PDV1
    Conserved Domains (1) summary
    smart00263
    Location:19147
    LYZ1; Alpha-lactalbumin / lysozyme C

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    52906810..52912154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078440.1XP_038934368.1  lysozyme C-1 isoform X1

    Related
    ENSRNOP00000007747.5, ENSRNOT00000007747.8
    Conserved Domains (1) summary
    smart00263
    Location:19191
    LYZ1; Alpha-lactalbumin / lysozyme C
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