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Hspb6 heat shock protein, alpha-crystallin-related, B6 [ Mus musculus (house mouse) ]

Gene ID: 243912, updated on 23-Jun-2021

Summary

Official Symbol
Hspb6provided by MGI
Official Full Name
heat shock protein, alpha-crystallin-related, B6provided by MGI
Primary source
MGI:MGI:2685325
See related
Ensembl:ENSMUSG00000036854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hsp; Gm479; Hsp20; AA387366
Expression
Biased expression in heart adult (RPKM 535.2), mammary gland adult (RPKM 143.4) and 8 other tissues See more
Orthologs
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Genomic context

See Hspb6 in Genome Data Viewer
Location:
7; 7 B1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30251961..30254868)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30552535..30555443)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31338321..31340458)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 33 Neighboring gene proline and serine rich 3 Neighboring gene microRNA 9769 Neighboring gene lin-37 DREAM MuvB core complex component Neighboring gene presenilin enhancer gamma secretase subunit Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 Neighboring gene IGF-like family receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107687

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of eye lens IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock protein beta-6
Names
cardiac heat shock protein p20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012401.3NP_001012401.1  heat shock protein beta-6 isoform 1

    See identical proteins and their annotated locations for NP_001012401.1

    Status: VALIDATED

    Source sequence(s)
    BC089621, BQ176401, CK627709
    Consensus CDS
    CCDS21097.1
    UniProtKB/Swiss-Prot
    Q5EBG6
    Related
    ENSMUSP00000039172.8, ENSMUST00000044048.8
    Conserved Domains (2) summary
    cd06478
    Location:66148
    ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...
    pfam00525
    Location:556
    Crystallin; Alpha crystallin A chain, N terminal
  2. NM_001364179.1NP_001351108.1  heat shock protein beta-6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK144390, BQ176401
    Related
    ENSMUST00000126989.8
    Conserved Domains (1) summary
    cl00175
    Location:889
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RNA

  1. NR_157095.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is represented as non-coding because it lacks the open reading frame found in variant 1.
    Source sequence(s)
    BC051228, BQ176401, BY198268
    Related
    ENSMUST00000123355.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30251961..30254868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539957.5XP_006540020.1  heat shock protein beta-6 isoform X1

    Conserved Domains (1) summary
    cd06478
    Location:47129
    ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...
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