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Dnai4 dynein axonemal intermediate chain 4 [ Mus musculus (house mouse) ]

Gene ID: 242584, updated on 9-Oct-2021

Summary

Official Symbol
Dnai4provided by MGI
Official Full Name
dynein axonemal intermediate chain 4provided by MGI
Primary source
MGI:MGI:2385328
See related
Ensembl:ENSMUSG00000035126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr78; BC028975
Expression
Biased expression in thymus adult (RPKM 5.9), testis adult (RPKM 5.6) and 12 other tissues See more
Orthologs
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Genomic context

See Dnai4 in Genome Data Viewer
Location:
4; 4 C6
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102895262..102971521, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103038065..103114299, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (102710670..102786904, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 5 Neighboring gene expressed sequence BB031773 Neighboring gene insulin-like 5 Neighboring gene MEIR1 treanscription regulator Neighboring gene solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC31722, MGC38950

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cilium movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of axonemal dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of axonemal dynein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein axonemal intermediate chain 4; WD repeat-containing protein 78
Names
WD repeat domain 78
dynein intermediate chain 4, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146254.4NP_666366.4  dynein axonemal intermediate chain 4

    See identical proteins and their annotated locations for NP_666366.4

    Status: VALIDATED

    Source sequence(s)
    AK030997, AL844176, BC028975, CF742041
    Consensus CDS
    CCDS38824.3
    UniProtKB/Swiss-Prot
    E9PYY5
    Related
    ENSMUSP00000102481.4, ENSMUST00000106868.4
    Conserved Domains (2) summary
    COG2319
    Location:444790
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:498542
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    102895262..102971521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164129.1XP_036020022.1  WD repeat-containing protein 78 isoform X1

    Conserved Domains (2) summary
    COG2319
    Location:444792
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:498542
    7WD40; WD40 repeat [structural motif]
  2. XM_030253560.2XP_030109420.1  WD repeat-containing protein 78 isoform X3

    Conserved Domains (2) summary
    COG2319
    Location:401749
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:455499
    7WD40; WD40 repeat [structural motif]
  3. XM_030253559.2XP_030109419.1  WD repeat-containing protein 78 isoform X2

    Conserved Domains (2) summary
    COG2319
    Location:441763
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:469513
    7WD40; WD40 repeat [structural motif]
  4. XM_030253561.1XP_030109421.1  WD repeat-containing protein 78 isoform X4

    Conserved Domains (2) summary
    COG2319
    Location:314662
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:368412
    7WD40; WD40 repeat [structural motif]
  5. XM_030253562.2XP_030109422.1  WD repeat-containing protein 78 isoform X5

    Conserved Domains (2) summary
    COG2319
    Location:195543
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:249293
    7WD40; WD40 repeat [structural motif]
  6. XM_017320218.3XP_017175707.1  WD repeat-containing protein 78 isoform X8

  7. XM_006503078.5XP_006503141.1  WD repeat-containing protein 78 isoform X7

  8. XM_006503077.5XP_006503140.1  WD repeat-containing protein 78 isoform X6

RNA

  1. XR_004941896.1 RNA Sequence

  2. XR_376319.5 RNA Sequence

    Related
    ENSMUST00000036557.15
  3. XR_004941895.1 RNA Sequence

  4. XR_376318.4 RNA Sequence

    Related
    ENSMUST00000116316.10
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