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Insl5 insulin-like 5 [ Mus musculus (house mouse) ]

Gene ID: 23919, updated on 23-Jun-2021

Summary

Official Symbol
Insl5provided by MGI
Official Full Name
insulin-like 5provided by MGI
Primary source
MGI:MGI:1346085
See related
Ensembl:ENSMUSG00000066090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RI; RIF2
Expression
Biased expression in colon adult (RPKM 40.9) and thymus adult (RPKM 3.7) See more
Orthologs
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Genomic context

See Insl5 in Genome Data Viewer
Location:
4 C6; 4 47.27 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102875069..102884468, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103017872..103027271, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (102690477..102699333, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like (endophilin) interacting protein 1 Neighboring gene predicted gene 12709 Neighboring gene dynein light chain Tctex-type 5 Neighboring gene expressed sequence BB031773 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene MEIR1 treanscription regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
insulin-like peptide INSL5
Names
relaxin/insulin-like factor 2
relaxin/insulin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290648.2NP_001277577.1  insulin-like peptide INSL5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001277577.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732543, BX004765
    Consensus CDS
    CCDS71431.1
    UniProtKB/Swiss-Prot
    Q9WUG6
    UniProtKB/TrEMBL
    A2AIY3
    Related
    ENSMUSP00000102482.3, ENSMUST00000106869.3
    Conserved Domains (1) summary
    cd04365
    Location:35145
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  2. NM_011831.2NP_035961.1  insulin-like peptide INSL5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_035961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF133817
    Consensus CDS
    CCDS18406.1
    UniProtKB/Swiss-Prot
    Q9WUG6
    Related
    ENSMUSP00000081416.6, ENSMUST00000084382.6
    Conserved Domains (1) summary
    cd04365
    Location:25135
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    102875069..102884468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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