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Als2cl ALS2 C-terminal like [ Mus musculus (house mouse) ]

Gene ID: 235633, updated on 16-Oct-2021

Summary

Official Symbol
Als2clprovided by MGI
Official Full Name
ALS2 C-terminal likeprovided by MGI
Primary source
MGI:MGI:2447532
See related
Ensembl:ENSMUSG00000044037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
79H19D; 79H19E; BC022645; mRn.49018; D930044G19Rik
Expression
Broad expression in lung adult (RPKM 21.1), thymus adult (RPKM 17.2) and 19 other tissues See more
Orthologs
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Genomic context

See Als2cl in Genome Data Viewer
Location:
9 F2; 9 60.79 cM
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110709203..110729598)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110880120..110900530)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (110782678..110803034)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protease, serine 50 Neighboring gene transmembrane inner ear Neighboring gene family with sequence similarity 240 member A Neighboring gene teratocarcinoma-derived growth factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endosome organization ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ALS2 C-terminal-like protein
Names
mFLJ00189 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146059.1NP_001139531.1  ALS2 C-terminal-like protein

    See identical proteins and their annotated locations for NP_001139531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK030815, AK053076, BE336122, BF715088, CJ114324
    Consensus CDS
    CCDS23579.1
    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Related
    ENSMUSP00000123304.2, ENSMUST00000130386.8
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  2. NM_001146060.1NP_001139532.1  ALS2 C-terminal-like protein

    See identical proteins and their annotated locations for NP_001139532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK030815, AK053076, BE336122, BF715088, BY721464
    Consensus CDS
    CCDS23579.1
    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Related
    ENSMUSP00000115718.2, ENSMUST00000155014.2
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  3. NM_146228.4NP_666340.3  ALS2 C-terminal-like protein

    See identical proteins and their annotated locations for NP_666340.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK030815, AK053076, BE336122, BF715088, CJ114324
    Consensus CDS
    CCDS23579.1
    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Related
    ENSMUSP00000081989.3, ENSMUST00000084926.9
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain

RNA

  1. NR_153354.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139378, BF715088

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110709203..110729598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313354.3XP_017168843.1  ALS2 C-terminal-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  2. XM_017313358.3XP_017168847.1  ALS2 C-terminal-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  3. XM_006512103.4XP_006512166.1  ALS2 C-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512166.1

    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  4. XM_017313356.2XP_017168845.1  ALS2 C-terminal-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  5. XM_017313355.2XP_017168844.1  ALS2 C-terminal-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  6. XM_017313357.2XP_017168846.1  ALS2 C-terminal-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q60I26
    UniProtKB/TrEMBL
    A0A0R4J1X4
    Conserved Domains (3) summary
    PLN03185
    Location:357550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223321
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:835937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  7. XM_030244350.1XP_030100210.1  ALS2 C-terminal-like protein isoform X2

    Related
    ENSMUST00000156673.2
    Conserved Domains (3) summary
    PLN03185
    Location:171364
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:37135
    PH-like; Pleckstrin homology-like domain
    cl19569
    Location:649751
    VPS9; Vacuolar sorting protein 9 (VPS9) domain

RNA

  1. XR_003947892.2 RNA Sequence

  2. XR_004935433.1 RNA Sequence

  3. XR_001778896.2 RNA Sequence

  4. XR_003947893.2 RNA Sequence

  5. XR_003947890.2 RNA Sequence

  6. XR_003947891.2 RNA Sequence

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