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Gckr glucokinase regulatory protein [ Mus musculus (house mouse) ]

Gene ID: 231103, updated on 23-Jun-2021

Summary

Official Symbol
Gckrprovided by MGI
Official Full Name
glucokinase regulatory proteinprovided by MGI
Primary source
MGI:MGI:1096345
See related
Ensembl:ENSMUSG00000059434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GK; GKRP
Expression
Biased expression in liver adult (RPKM 48.2), liver E18 (RPKM 19.1) and 2 other tissues See more
Orthologs
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Genomic context

See Gckr in Genome Data Viewer
Location:
5 B1; 5 17.27 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31454594..31484646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31297266..31327302)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (31599954..31629675)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 172 Neighboring gene fibronectin type III domain containing 4 Neighboring gene predicted gene, 19457 Neighboring gene predicted gene, 40275

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC19300

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate derivative binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables fructose-6-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose-6-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of glucokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to fructose IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to fructose ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glucokinase regulatory protein
Names
glucokinase regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374741.1NP_001361670.1  glucokinase regulatory protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC114619
    Consensus CDS
    CCDS89900.1
    Related
    ENSMUSP00000144202.2, ENSMUST00000201166.4
    Conserved Domains (3) summary
    PRK05441
    Location:482605
    murQ; N-acetylmuramic acid-6-phosphate etherase; Reviewed
    PRK12570
    Location:30277
    PRK12570; N-acetylmuramic acid-6-phosphate etherase; Reviewed
    cl00389
    Location:293555
    SIS; SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
  2. NM_144909.2NP_659158.1  glucokinase regulatory protein isoform 2

    See identical proteins and their annotated locations for NP_659158.1

    Status: VALIDATED

    Source sequence(s)
    AC114619
    Consensus CDS
    CCDS19182.1
    UniProtKB/Swiss-Prot
    Q91X44
    Related
    ENSMUSP00000072084.6, ENSMUST00000072228.9
    Conserved Domains (2) summary
    PRK12570
    Location:30277
    PRK12570; N-acetylmuramic acid-6-phosphate etherase; Reviewed
    cl00389
    Location:293366
    SIS; SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31454594..31484646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503882.5XP_006503945.1  glucokinase regulatory protein isoform X1

    Conserved Domains (3) summary
    PRK05441
    Location:464587
    murQ; N-acetylmuramic acid-6-phosphate etherase; Reviewed
    PRK12570
    Location:30259
    PRK12570; N-acetylmuramic acid-6-phosphate etherase; Reviewed
    cl00389
    Location:275537
    SIS; SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
  2. XM_006503883.5XP_006503946.1  glucokinase regulatory protein isoform X2

    Conserved Domains (2) summary
    PRK05441
    Location:430553
    murQ; N-acetylmuramic acid-6-phosphate etherase; Reviewed
    cl00389
    Location:57221
    SIS; SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
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